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Decreased CRRT Filter Lifespan in COVID-19 ICU Patients
(1) Background: Increased thromboembolic events and an increased need for continuous renal replacement therapy (CRRT) have been frequently reported in COVID-19 patients. Our aim was to investigate CRRT filter lifespan in intensive care unit (ICU) COVID-19 patients. (2) Methods: We compared CRRT adju...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123645/ https://www.ncbi.nlm.nih.gov/pubmed/33925999 http://dx.doi.org/10.3390/jcm10091873 |
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author | Legouis, David Montalbano, Maria F. Siegenthaler, Nils Thieffry, Camille Assouline, Benjamin Marti, Pierre Emmanuel Sgardello, Sebastian D. Andreetta, Claudio Binvignat, Céline Pugin, Jérôme Heidegger, Claudia Sangla, Frédéric |
author_facet | Legouis, David Montalbano, Maria F. Siegenthaler, Nils Thieffry, Camille Assouline, Benjamin Marti, Pierre Emmanuel Sgardello, Sebastian D. Andreetta, Claudio Binvignat, Céline Pugin, Jérôme Heidegger, Claudia Sangla, Frédéric |
author_sort | Legouis, David |
collection | PubMed |
description | (1) Background: Increased thromboembolic events and an increased need for continuous renal replacement therapy (CRRT) have been frequently reported in COVID-19 patients. Our aim was to investigate CRRT filter lifespan in intensive care unit (ICU) COVID-19 patients. (2) Methods: We compared CRRT adjusted circuit lifespan in COVID-19 patients admitted for SARS-CoV-2 infection to a control group of patients admitted for septic shock of pulmonary origin other than COVID-19. Both groups underwent at least one session of CRRT for AKI. (3) Results: Twenty-six patients (13 in each group) were included. We analysed 117 CRRT circuits (80 in the COVID-19 group and 37 in the control group). The adjusted filter lifespan was shorter in the COVID-19 group (17 vs. 39 h, p < 0.001). This trend persisted after adjustment for confounding factors (−14 h, p = 0.037). Before CRRT circuit clotting, the COVID-19 group had a more procoagulant profile despite higher heparin infusion rates. Furthermore, we reported a decreased relation between activated partial thromboplastin time (aPTT) and cumulative heparin dose in COVID-19 patients when compared to historical data of 23,058 patients, suggesting a heparin resistance. (4) Conclusion: COVID-19 patients displayed a shorter CRRT filter lifespan that could be related to a procoagulant profile and heparin resistance. |
format | Online Article Text |
id | pubmed-8123645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81236452021-05-16 Decreased CRRT Filter Lifespan in COVID-19 ICU Patients Legouis, David Montalbano, Maria F. Siegenthaler, Nils Thieffry, Camille Assouline, Benjamin Marti, Pierre Emmanuel Sgardello, Sebastian D. Andreetta, Claudio Binvignat, Céline Pugin, Jérôme Heidegger, Claudia Sangla, Frédéric J Clin Med Article (1) Background: Increased thromboembolic events and an increased need for continuous renal replacement therapy (CRRT) have been frequently reported in COVID-19 patients. Our aim was to investigate CRRT filter lifespan in intensive care unit (ICU) COVID-19 patients. (2) Methods: We compared CRRT adjusted circuit lifespan in COVID-19 patients admitted for SARS-CoV-2 infection to a control group of patients admitted for septic shock of pulmonary origin other than COVID-19. Both groups underwent at least one session of CRRT for AKI. (3) Results: Twenty-six patients (13 in each group) were included. We analysed 117 CRRT circuits (80 in the COVID-19 group and 37 in the control group). The adjusted filter lifespan was shorter in the COVID-19 group (17 vs. 39 h, p < 0.001). This trend persisted after adjustment for confounding factors (−14 h, p = 0.037). Before CRRT circuit clotting, the COVID-19 group had a more procoagulant profile despite higher heparin infusion rates. Furthermore, we reported a decreased relation between activated partial thromboplastin time (aPTT) and cumulative heparin dose in COVID-19 patients when compared to historical data of 23,058 patients, suggesting a heparin resistance. (4) Conclusion: COVID-19 patients displayed a shorter CRRT filter lifespan that could be related to a procoagulant profile and heparin resistance. MDPI 2021-04-26 /pmc/articles/PMC8123645/ /pubmed/33925999 http://dx.doi.org/10.3390/jcm10091873 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Legouis, David Montalbano, Maria F. Siegenthaler, Nils Thieffry, Camille Assouline, Benjamin Marti, Pierre Emmanuel Sgardello, Sebastian D. Andreetta, Claudio Binvignat, Céline Pugin, Jérôme Heidegger, Claudia Sangla, Frédéric Decreased CRRT Filter Lifespan in COVID-19 ICU Patients |
title | Decreased CRRT Filter Lifespan in COVID-19 ICU Patients |
title_full | Decreased CRRT Filter Lifespan in COVID-19 ICU Patients |
title_fullStr | Decreased CRRT Filter Lifespan in COVID-19 ICU Patients |
title_full_unstemmed | Decreased CRRT Filter Lifespan in COVID-19 ICU Patients |
title_short | Decreased CRRT Filter Lifespan in COVID-19 ICU Patients |
title_sort | decreased crrt filter lifespan in covid-19 icu patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123645/ https://www.ncbi.nlm.nih.gov/pubmed/33925999 http://dx.doi.org/10.3390/jcm10091873 |
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