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Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors
Liquid biopsy, as a non-invasive technique for cancer diagnosis, has emerged as a major step forward in conquering tumors. Current practice in diagnosis of central nervous system (CNS) tumors involves invasive acquisition of tumor biopsy upon detection of tumor on neuroimaging. Liquid biopsy enables...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123653/ https://www.ncbi.nlm.nih.gov/pubmed/33925295 http://dx.doi.org/10.3390/ijms22094548 |
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author | Bunda, Severa Zuccato, Jeffrey A. Voisin, Mathew R. Wang, Justin Z. Nassiri, Farshad Patil, Vikas Mansouri, Sheila Zadeh, Gelareh |
author_facet | Bunda, Severa Zuccato, Jeffrey A. Voisin, Mathew R. Wang, Justin Z. Nassiri, Farshad Patil, Vikas Mansouri, Sheila Zadeh, Gelareh |
author_sort | Bunda, Severa |
collection | PubMed |
description | Liquid biopsy, as a non-invasive technique for cancer diagnosis, has emerged as a major step forward in conquering tumors. Current practice in diagnosis of central nervous system (CNS) tumors involves invasive acquisition of tumor biopsy upon detection of tumor on neuroimaging. Liquid biopsy enables non-invasive, rapid, precise and, in particular, real-time cancer detection, prognosis and treatment monitoring, especially for CNS tumors. This approach can also uncover the heterogeneity of these tumors and will likely replace tissue biopsy in the future. Key components of liquid biopsy mainly include circulating tumor cells (CTC), circulating tumor nucleic acids (ctDNA, miRNA) and exosomes and samples can be obtained from the cerebrospinal fluid, plasma and serum of patients with CNS malignancies. This review covers current progress in application of liquid biopsies for diagnosis and monitoring of CNS malignancies. |
format | Online Article Text |
id | pubmed-8123653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81236532021-05-16 Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors Bunda, Severa Zuccato, Jeffrey A. Voisin, Mathew R. Wang, Justin Z. Nassiri, Farshad Patil, Vikas Mansouri, Sheila Zadeh, Gelareh Int J Mol Sci Review Liquid biopsy, as a non-invasive technique for cancer diagnosis, has emerged as a major step forward in conquering tumors. Current practice in diagnosis of central nervous system (CNS) tumors involves invasive acquisition of tumor biopsy upon detection of tumor on neuroimaging. Liquid biopsy enables non-invasive, rapid, precise and, in particular, real-time cancer detection, prognosis and treatment monitoring, especially for CNS tumors. This approach can also uncover the heterogeneity of these tumors and will likely replace tissue biopsy in the future. Key components of liquid biopsy mainly include circulating tumor cells (CTC), circulating tumor nucleic acids (ctDNA, miRNA) and exosomes and samples can be obtained from the cerebrospinal fluid, plasma and serum of patients with CNS malignancies. This review covers current progress in application of liquid biopsies for diagnosis and monitoring of CNS malignancies. MDPI 2021-04-27 /pmc/articles/PMC8123653/ /pubmed/33925295 http://dx.doi.org/10.3390/ijms22094548 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bunda, Severa Zuccato, Jeffrey A. Voisin, Mathew R. Wang, Justin Z. Nassiri, Farshad Patil, Vikas Mansouri, Sheila Zadeh, Gelareh Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors |
title | Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors |
title_full | Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors |
title_fullStr | Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors |
title_full_unstemmed | Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors |
title_short | Liquid Biomarkers for Improved Diagnosis and Classification of CNS Tumors |
title_sort | liquid biomarkers for improved diagnosis and classification of cns tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123653/ https://www.ncbi.nlm.nih.gov/pubmed/33925295 http://dx.doi.org/10.3390/ijms22094548 |
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