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Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA(trp) during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123658/ https://www.ncbi.nlm.nih.gov/pubmed/33926067 http://dx.doi.org/10.3390/ijms22094523 |
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author | Ahn, Young Ha Oh, Se-Chan Zhou, Shengtao Kim, Tae-Don |
author_facet | Ahn, Young Ha Oh, Se-Chan Zhou, Shengtao Kim, Tae-Don |
author_sort | Ahn, Young Ha |
collection | PubMed |
description | Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA(trp) during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of action of WRS are still at an emerging stage. This review summarizes the involvement of WRS in human diseases. We hope that this will encourage further investigation into WRS as a potential target for drug development in various pathological states including infection, tumorigenesis, and autoimmune and brain diseases. |
format | Online Article Text |
id | pubmed-8123658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81236582021-05-16 Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target Ahn, Young Ha Oh, Se-Chan Zhou, Shengtao Kim, Tae-Don Int J Mol Sci Review Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA(trp) during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of action of WRS are still at an emerging stage. This review summarizes the involvement of WRS in human diseases. We hope that this will encourage further investigation into WRS as a potential target for drug development in various pathological states including infection, tumorigenesis, and autoimmune and brain diseases. MDPI 2021-04-26 /pmc/articles/PMC8123658/ /pubmed/33926067 http://dx.doi.org/10.3390/ijms22094523 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ahn, Young Ha Oh, Se-Chan Zhou, Shengtao Kim, Tae-Don Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target |
title | Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target |
title_full | Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target |
title_fullStr | Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target |
title_full_unstemmed | Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target |
title_short | Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target |
title_sort | tryptophanyl-trna synthetase as a potential therapeutic target |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123658/ https://www.ncbi.nlm.nih.gov/pubmed/33926067 http://dx.doi.org/10.3390/ijms22094523 |
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