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Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target

Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA(trp) during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and...

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Autores principales: Ahn, Young Ha, Oh, Se-Chan, Zhou, Shengtao, Kim, Tae-Don
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123658/
https://www.ncbi.nlm.nih.gov/pubmed/33926067
http://dx.doi.org/10.3390/ijms22094523
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author Ahn, Young Ha
Oh, Se-Chan
Zhou, Shengtao
Kim, Tae-Don
author_facet Ahn, Young Ha
Oh, Se-Chan
Zhou, Shengtao
Kim, Tae-Don
author_sort Ahn, Young Ha
collection PubMed
description Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA(trp) during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of action of WRS are still at an emerging stage. This review summarizes the involvement of WRS in human diseases. We hope that this will encourage further investigation into WRS as a potential target for drug development in various pathological states including infection, tumorigenesis, and autoimmune and brain diseases.
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spelling pubmed-81236582021-05-16 Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target Ahn, Young Ha Oh, Se-Chan Zhou, Shengtao Kim, Tae-Don Int J Mol Sci Review Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA(trp) during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of action of WRS are still at an emerging stage. This review summarizes the involvement of WRS in human diseases. We hope that this will encourage further investigation into WRS as a potential target for drug development in various pathological states including infection, tumorigenesis, and autoimmune and brain diseases. MDPI 2021-04-26 /pmc/articles/PMC8123658/ /pubmed/33926067 http://dx.doi.org/10.3390/ijms22094523 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ahn, Young Ha
Oh, Se-Chan
Zhou, Shengtao
Kim, Tae-Don
Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
title Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
title_full Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
title_fullStr Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
title_full_unstemmed Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
title_short Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
title_sort tryptophanyl-trna synthetase as a potential therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123658/
https://www.ncbi.nlm.nih.gov/pubmed/33926067
http://dx.doi.org/10.3390/ijms22094523
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