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Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly bec...

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Autores principales: Gerussi, Alessio, Natalini, Ambra, Antonangeli, Fabrizio, Mancuso, Clara, Agostinetto, Elisa, Barisani, Donatella, Di Rosa, Francesca, Andrade, Raul, Invernizzi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123708/
https://www.ncbi.nlm.nih.gov/pubmed/33925355
http://dx.doi.org/10.3390/ijms22094557
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author Gerussi, Alessio
Natalini, Ambra
Antonangeli, Fabrizio
Mancuso, Clara
Agostinetto, Elisa
Barisani, Donatella
Di Rosa, Francesca
Andrade, Raul
Invernizzi, Pietro
author_facet Gerussi, Alessio
Natalini, Ambra
Antonangeli, Fabrizio
Mancuso, Clara
Agostinetto, Elisa
Barisani, Donatella
Di Rosa, Francesca
Andrade, Raul
Invernizzi, Pietro
author_sort Gerussi, Alessio
collection PubMed
description Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.
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spelling pubmed-81237082021-05-16 Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models Gerussi, Alessio Natalini, Ambra Antonangeli, Fabrizio Mancuso, Clara Agostinetto, Elisa Barisani, Donatella Di Rosa, Francesca Andrade, Raul Invernizzi, Pietro Int J Mol Sci Review Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level. MDPI 2021-04-27 /pmc/articles/PMC8123708/ /pubmed/33925355 http://dx.doi.org/10.3390/ijms22094557 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gerussi, Alessio
Natalini, Ambra
Antonangeli, Fabrizio
Mancuso, Clara
Agostinetto, Elisa
Barisani, Donatella
Di Rosa, Francesca
Andrade, Raul
Invernizzi, Pietro
Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
title Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
title_full Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
title_fullStr Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
title_full_unstemmed Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
title_short Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models
title_sort immune-mediated drug-induced liver injury: immunogenetics and experimental models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123708/
https://www.ncbi.nlm.nih.gov/pubmed/33925355
http://dx.doi.org/10.3390/ijms22094557
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