CHEK2 Pathogenic Variants in Greek Breast Cancer Patients: Evidence for Strong Associations with Estrogen Receptor Positivity, Overuse of Risk-Reducing Procedures and Population Founder Effects

SIMPLE SUMMARY: CHEK2 germline pathogenic variants are identified at a relatively high frequency among hereditary breast cancer cases and are known to be associated with intermediate breast cancer risk i.e., 2–2.5-fold increase, compared to the general population. Histopathological characteristics a...

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Detalles Bibliográficos
Autores principales: Apostolou, Paraskevi, Dellatola, Vasiliki, Papadimitriou, Christos, Kalfakakou, Despoina, Fountzilas, Elena, Faliakou, Eleni, Fountzilas, Georgios, Romanidou, Ourania, Konstantopoulou, Irene, Fostira, Florentia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123864/
https://www.ncbi.nlm.nih.gov/pubmed/33925588
http://dx.doi.org/10.3390/cancers13092106

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