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The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients
Hyperuricemia is a significant risk factor for cardiovascular morbidity and chronic kidney disease progression. IgA nephropathy (IgAN) is a well-known primary glomerular nephropathy. Hyperuricemia is associated with a poor prognosis in IgAN patients. We evaluated the association of hyperuricemia wit...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123880/ https://www.ncbi.nlm.nih.gov/pubmed/33925441 http://dx.doi.org/10.3390/jcm10091885 |
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author | Choi, Won Jung Hong, Yu A Min, Ji Won Koh, Eun Sil Kim, Hyung Duk Ban, Tae Hyun Kim, Young Soo Kim, Yong Kyun Shin, Seok Joon Kim, Seok Young Kim, Young Ok Yang, Chul Woo Chang, Yoon-Kyung |
author_facet | Choi, Won Jung Hong, Yu A Min, Ji Won Koh, Eun Sil Kim, Hyung Duk Ban, Tae Hyun Kim, Young Soo Kim, Yong Kyun Shin, Seok Joon Kim, Seok Young Kim, Young Ok Yang, Chul Woo Chang, Yoon-Kyung |
author_sort | Choi, Won Jung |
collection | PubMed |
description | Hyperuricemia is a significant risk factor for cardiovascular morbidity and chronic kidney disease progression. IgA nephropathy (IgAN) is a well-known primary glomerular nephropathy. Hyperuricemia is associated with a poor prognosis in IgAN patients. We evaluated the association of hyperuricemia with the histopathological severity of IgAN in male and female patients; 658 patients diagnosed with IgAN via kidney biopsy were initially included. Baseline patient data were collected by eight university hospitals affiliated with the College of Medicine of the Catholic University of Korea. Pathological features were independently evaluated by eight expert pathologists working in the hospitals, and the consensus was reached. Of the initial 658 patients, 517 were finally included (253 males and 264 females). Hyperuricemia was defined as a serum uric acid (UA) level >7.0 mg/dL for males and >5.6 mg/dL for females; 108 (42.7%) males and 95 (35.9%) females exhibited hyperuricemia. Compared to the patients with normal UA levels, the global glomerulosclerosis, segmental sclerosis, mesangial matrix expansion (MME), endocapillary proliferation (ECP), interstitial fibrosis (IF), and tubular atrophy (TA) scores were higher in hyperuricemic males and females. In multivariable linear regression, the serum UA level correlated significantly with the MME, ECP, IF, and TA scores of female IgAN patients only. |
format | Online Article Text |
id | pubmed-8123880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81238802021-05-16 The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients Choi, Won Jung Hong, Yu A Min, Ji Won Koh, Eun Sil Kim, Hyung Duk Ban, Tae Hyun Kim, Young Soo Kim, Yong Kyun Shin, Seok Joon Kim, Seok Young Kim, Young Ok Yang, Chul Woo Chang, Yoon-Kyung J Clin Med Article Hyperuricemia is a significant risk factor for cardiovascular morbidity and chronic kidney disease progression. IgA nephropathy (IgAN) is a well-known primary glomerular nephropathy. Hyperuricemia is associated with a poor prognosis in IgAN patients. We evaluated the association of hyperuricemia with the histopathological severity of IgAN in male and female patients; 658 patients diagnosed with IgAN via kidney biopsy were initially included. Baseline patient data were collected by eight university hospitals affiliated with the College of Medicine of the Catholic University of Korea. Pathological features were independently evaluated by eight expert pathologists working in the hospitals, and the consensus was reached. Of the initial 658 patients, 517 were finally included (253 males and 264 females). Hyperuricemia was defined as a serum uric acid (UA) level >7.0 mg/dL for males and >5.6 mg/dL for females; 108 (42.7%) males and 95 (35.9%) females exhibited hyperuricemia. Compared to the patients with normal UA levels, the global glomerulosclerosis, segmental sclerosis, mesangial matrix expansion (MME), endocapillary proliferation (ECP), interstitial fibrosis (IF), and tubular atrophy (TA) scores were higher in hyperuricemic males and females. In multivariable linear regression, the serum UA level correlated significantly with the MME, ECP, IF, and TA scores of female IgAN patients only. MDPI 2021-04-27 /pmc/articles/PMC8123880/ /pubmed/33925441 http://dx.doi.org/10.3390/jcm10091885 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Won Jung Hong, Yu A Min, Ji Won Koh, Eun Sil Kim, Hyung Duk Ban, Tae Hyun Kim, Young Soo Kim, Yong Kyun Shin, Seok Joon Kim, Seok Young Kim, Young Ok Yang, Chul Woo Chang, Yoon-Kyung The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients |
title | The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients |
title_full | The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients |
title_fullStr | The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients |
title_full_unstemmed | The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients |
title_short | The Serum Uric Acid Level Is Related to the More Severe Renal Histopathology of Female IgA Nephropathy Patients |
title_sort | serum uric acid level is related to the more severe renal histopathology of female iga nephropathy patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123880/ https://www.ncbi.nlm.nih.gov/pubmed/33925441 http://dx.doi.org/10.3390/jcm10091885 |
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