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Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus

PURPOSE: This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. METHODS: All infants were voluntarily chosen by their mothers an...

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Autores principales: Zhou, Mingshu, Li, Li, Han, Lirong, Sun, Fangli, Yi, Nuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123968/
https://www.ncbi.nlm.nih.gov/pubmed/34007207
http://dx.doi.org/10.2147/IJGM.S289804
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author Zhou, Mingshu
Li, Li
Han, Lirong
Sun, Fangli
Yi, Nuo
author_facet Zhou, Mingshu
Li, Li
Han, Lirong
Sun, Fangli
Yi, Nuo
author_sort Zhou, Mingshu
collection PubMed
description PURPOSE: This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. METHODS: All infants were voluntarily chosen by their mothers and divided into breast-feeding group and formula-feeding group, which were divided into three subgroups, respectively: HBV-DNA negative (HBV-) group, low viral load (LVL) group and high viral load (HVL) group. RESULTS: HBV load in colostrum and mature milk were both significantly lower than in serum (P < 0.001). The positive rate of HBV-DNA in colostrum was positively correlated with HBV load in serum, significantly higher than that of the HBV-Group in colostrum in the LVL Group (P < 0.05), and the HVL Group was significantly higher than the LVL Group (P < 0.001). The analysis of risk factors of HBV infection in infants showed that breast-feeding and HBsAg positive in colostrum did not increase the risks of HBV infection of infants (P > 0.05). CONCLUSION: Breast-feeding is safe for infants with HBV-infected mothers who receive active immunization combined with passive immunization. As well, breast-feeding will neither increase the risks of HBV infection for infants nor weaken their immunity to HBV. However, breast-feeding shall be cautiously applied to pregnant women with high viral load.
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spelling pubmed-81239682021-05-17 Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus Zhou, Mingshu Li, Li Han, Lirong Sun, Fangli Yi, Nuo Int J Gen Med Original Research PURPOSE: This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. METHODS: All infants were voluntarily chosen by their mothers and divided into breast-feeding group and formula-feeding group, which were divided into three subgroups, respectively: HBV-DNA negative (HBV-) group, low viral load (LVL) group and high viral load (HVL) group. RESULTS: HBV load in colostrum and mature milk were both significantly lower than in serum (P < 0.001). The positive rate of HBV-DNA in colostrum was positively correlated with HBV load in serum, significantly higher than that of the HBV-Group in colostrum in the LVL Group (P < 0.05), and the HVL Group was significantly higher than the LVL Group (P < 0.001). The analysis of risk factors of HBV infection in infants showed that breast-feeding and HBsAg positive in colostrum did not increase the risks of HBV infection of infants (P > 0.05). CONCLUSION: Breast-feeding is safe for infants with HBV-infected mothers who receive active immunization combined with passive immunization. As well, breast-feeding will neither increase the risks of HBV infection for infants nor weaken their immunity to HBV. However, breast-feeding shall be cautiously applied to pregnant women with high viral load. Dove 2021-05-11 /pmc/articles/PMC8123968/ /pubmed/34007207 http://dx.doi.org/10.2147/IJGM.S289804 Text en © 2021 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhou, Mingshu
Li, Li
Han, Lirong
Sun, Fangli
Yi, Nuo
Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
title Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
title_full Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
title_fullStr Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
title_full_unstemmed Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
title_short Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
title_sort breast-feeding is not a risk factor of mother-to-child transmission of hepatitis b virus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123968/
https://www.ncbi.nlm.nih.gov/pubmed/34007207
http://dx.doi.org/10.2147/IJGM.S289804
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