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Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus
PURPOSE: This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. METHODS: All infants were voluntarily chosen by their mothers an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123968/ https://www.ncbi.nlm.nih.gov/pubmed/34007207 http://dx.doi.org/10.2147/IJGM.S289804 |
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author | Zhou, Mingshu Li, Li Han, Lirong Sun, Fangli Yi, Nuo |
author_facet | Zhou, Mingshu Li, Li Han, Lirong Sun, Fangli Yi, Nuo |
author_sort | Zhou, Mingshu |
collection | PubMed |
description | PURPOSE: This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. METHODS: All infants were voluntarily chosen by their mothers and divided into breast-feeding group and formula-feeding group, which were divided into three subgroups, respectively: HBV-DNA negative (HBV-) group, low viral load (LVL) group and high viral load (HVL) group. RESULTS: HBV load in colostrum and mature milk were both significantly lower than in serum (P < 0.001). The positive rate of HBV-DNA in colostrum was positively correlated with HBV load in serum, significantly higher than that of the HBV-Group in colostrum in the LVL Group (P < 0.05), and the HVL Group was significantly higher than the LVL Group (P < 0.001). The analysis of risk factors of HBV infection in infants showed that breast-feeding and HBsAg positive in colostrum did not increase the risks of HBV infection of infants (P > 0.05). CONCLUSION: Breast-feeding is safe for infants with HBV-infected mothers who receive active immunization combined with passive immunization. As well, breast-feeding will neither increase the risks of HBV infection for infants nor weaken their immunity to HBV. However, breast-feeding shall be cautiously applied to pregnant women with high viral load. |
format | Online Article Text |
id | pubmed-8123968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81239682021-05-17 Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus Zhou, Mingshu Li, Li Han, Lirong Sun, Fangli Yi, Nuo Int J Gen Med Original Research PURPOSE: This study aims at researching the content of hepatitis B virus (HBV) DNA in the breast milk of the mothers carrying HBV and investigating the effects of different feeding methods on mother-to-child transmission (MTCT) of HBV. METHODS: All infants were voluntarily chosen by their mothers and divided into breast-feeding group and formula-feeding group, which were divided into three subgroups, respectively: HBV-DNA negative (HBV-) group, low viral load (LVL) group and high viral load (HVL) group. RESULTS: HBV load in colostrum and mature milk were both significantly lower than in serum (P < 0.001). The positive rate of HBV-DNA in colostrum was positively correlated with HBV load in serum, significantly higher than that of the HBV-Group in colostrum in the LVL Group (P < 0.05), and the HVL Group was significantly higher than the LVL Group (P < 0.001). The analysis of risk factors of HBV infection in infants showed that breast-feeding and HBsAg positive in colostrum did not increase the risks of HBV infection of infants (P > 0.05). CONCLUSION: Breast-feeding is safe for infants with HBV-infected mothers who receive active immunization combined with passive immunization. As well, breast-feeding will neither increase the risks of HBV infection for infants nor weaken their immunity to HBV. However, breast-feeding shall be cautiously applied to pregnant women with high viral load. Dove 2021-05-11 /pmc/articles/PMC8123968/ /pubmed/34007207 http://dx.doi.org/10.2147/IJGM.S289804 Text en © 2021 Zhou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhou, Mingshu Li, Li Han, Lirong Sun, Fangli Yi, Nuo Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus |
title | Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus |
title_full | Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus |
title_fullStr | Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus |
title_full_unstemmed | Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus |
title_short | Breast-Feeding is Not a Risk Factor of Mother-to-Child Transmission of Hepatitis B Virus |
title_sort | breast-feeding is not a risk factor of mother-to-child transmission of hepatitis b virus |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123968/ https://www.ncbi.nlm.nih.gov/pubmed/34007207 http://dx.doi.org/10.2147/IJGM.S289804 |
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