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Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies

PURPOSE: To describe the predictive value of information on previous benign biopsy for the outcome of MRI-targeted biopsies. METHODS: An exploratory analysis was conducted using data from a prospective, multicenter, paired diagnostic study of 532 men undergoing diagnostics for prostate cancer during...

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Autores principales: Lantz, Anna, Haug, Erik Skaaheim, Picker, Wolfgang, Crippa, Alessio, Jäderling, Fredrik, Mortezavi, Ashkan, Nordström, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124045/
https://www.ncbi.nlm.nih.gov/pubmed/32472278
http://dx.doi.org/10.1007/s00345-020-03277-x
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author Lantz, Anna
Haug, Erik Skaaheim
Picker, Wolfgang
Crippa, Alessio
Jäderling, Fredrik
Mortezavi, Ashkan
Nordström, Tobias
author_facet Lantz, Anna
Haug, Erik Skaaheim
Picker, Wolfgang
Crippa, Alessio
Jäderling, Fredrik
Mortezavi, Ashkan
Nordström, Tobias
author_sort Lantz, Anna
collection PubMed
description PURPOSE: To describe the predictive value of information on previous benign biopsy for the outcome of MRI-targeted biopsies. METHODS: An exploratory analysis was conducted using data from a prospective, multicenter, paired diagnostic study of 532 men undergoing diagnostics for prostate cancer during 2016–2017. All men underwent 1.5 T MRI; systematic prostate biopsies; and MRI-targeted biopsies to MRI lesions with Prostate Imaging Reporting and Data System version 2, PI-RADS ≥ 3. The main outcome was numbers of detected prostate cancer characterized by grade group (GG) where GG ≥ 2 defined clinically significant cancer (csPCa). RESULTS: Men with previous biopsies had significantly more often negative MRI (26% vs. 17%, p < 0.05) compared to men without previous biopsies. Men with previous biopsies showed higher rates of benign biopsies (41% vs. 26%, p < 0.05) and lower rates of GG2 (17% vs. 30%, p < 0.05) and GG ≥ 3 (5% vs. 10%, p < 0.05) cancer. Biopsy-naïve men had higher proportions of highly suspicious MRI lesions (PIRADS 5; p < 0.05) and a higher proportion of significant cancer in those lesions (p = 0.05). In multivariate regression analysis, a previous benign prostate biopsy was associated with less than half the odds of csPCa (OR 0.38; 95% CI 0.20–0.71). CONCLUSION: In this large prospective multicenter trial, we showed that men with a previous prostate biopsy had higher proportions of MRIs without lesions and lower proportion of highly suspicious lesions than biopsy-naïve men. Further, biopsy-naïve men showed higher detection of clinically significant cancer when using MRI-targeted biopsies. Also, in the era of MRI-targeted biopsy strategies, biopsy history should be carefully considered in biopsy decisions. TRIAL REGISTRATION: NCT02788825 (ClinicalTrials.gov). Date of registration June 2, 2016. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00345-020-03277-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-81240452021-05-26 Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies Lantz, Anna Haug, Erik Skaaheim Picker, Wolfgang Crippa, Alessio Jäderling, Fredrik Mortezavi, Ashkan Nordström, Tobias World J Urol Original Article PURPOSE: To describe the predictive value of information on previous benign biopsy for the outcome of MRI-targeted biopsies. METHODS: An exploratory analysis was conducted using data from a prospective, multicenter, paired diagnostic study of 532 men undergoing diagnostics for prostate cancer during 2016–2017. All men underwent 1.5 T MRI; systematic prostate biopsies; and MRI-targeted biopsies to MRI lesions with Prostate Imaging Reporting and Data System version 2, PI-RADS ≥ 3. The main outcome was numbers of detected prostate cancer characterized by grade group (GG) where GG ≥ 2 defined clinically significant cancer (csPCa). RESULTS: Men with previous biopsies had significantly more often negative MRI (26% vs. 17%, p < 0.05) compared to men without previous biopsies. Men with previous biopsies showed higher rates of benign biopsies (41% vs. 26%, p < 0.05) and lower rates of GG2 (17% vs. 30%, p < 0.05) and GG ≥ 3 (5% vs. 10%, p < 0.05) cancer. Biopsy-naïve men had higher proportions of highly suspicious MRI lesions (PIRADS 5; p < 0.05) and a higher proportion of significant cancer in those lesions (p = 0.05). In multivariate regression analysis, a previous benign prostate biopsy was associated with less than half the odds of csPCa (OR 0.38; 95% CI 0.20–0.71). CONCLUSION: In this large prospective multicenter trial, we showed that men with a previous prostate biopsy had higher proportions of MRIs without lesions and lower proportion of highly suspicious lesions than biopsy-naïve men. Further, biopsy-naïve men showed higher detection of clinically significant cancer when using MRI-targeted biopsies. Also, in the era of MRI-targeted biopsy strategies, biopsy history should be carefully considered in biopsy decisions. TRIAL REGISTRATION: NCT02788825 (ClinicalTrials.gov). Date of registration June 2, 2016. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00345-020-03277-x) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-05-29 2021 /pmc/articles/PMC8124045/ /pubmed/32472278 http://dx.doi.org/10.1007/s00345-020-03277-x Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Lantz, Anna
Haug, Erik Skaaheim
Picker, Wolfgang
Crippa, Alessio
Jäderling, Fredrik
Mortezavi, Ashkan
Nordström, Tobias
Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies
title Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies
title_full Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies
title_fullStr Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies
title_full_unstemmed Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies
title_short Effect of information on prostate biopsy history on biopsy outcomes in the era of MRI-targeted biopsies
title_sort effect of information on prostate biopsy history on biopsy outcomes in the era of mri-targeted biopsies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124045/
https://www.ncbi.nlm.nih.gov/pubmed/32472278
http://dx.doi.org/10.1007/s00345-020-03277-x
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