Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs

Fragile X syndrome (FXS) is a neurodevelopmental disorder, characterized by intellectual disability and sensory deficits, caused by epigenetic silencing of the FMR1 gene and subsequent loss of its protein product, fragile X mental retardation protein (FMRP). Delays in synaptic and neuronal developme...

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Detalles Bibliográficos
Autores principales: Brighi, Carlo, Salaris, Federico, Soloperto, Alessandro, Cordella, Federica, Ghirga, Silvia, de Turris, Valeria, Rosito, Maria, Porceddu, Pier Francesca, D’Antoni, Chiara, Reggiani, Angelo, Rosa, Alessandro, Di Angelantonio, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124071/
https://www.ncbi.nlm.nih.gov/pubmed/33993189
http://dx.doi.org/10.1038/s41419-021-03776-8

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