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A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale

Photothermal therapy based on nanoparticles is a promising method for cancer treatment. However, there are still many limits in practical application. During photothermal therapy, improving therapeutic effect is contradictory to reducing overheating in healthy tissues. We should make the temperature...

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Detalles Bibliográficos
Autores principales: Jiang, Qingyun, Li, Xinlei, Yin, Chengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124147/
https://www.ncbi.nlm.nih.gov/pubmed/34063151
http://dx.doi.org/10.3390/ma14092407
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author Jiang, Qingyun
Li, Xinlei
Yin, Chengping
author_facet Jiang, Qingyun
Li, Xinlei
Yin, Chengping
author_sort Jiang, Qingyun
collection PubMed
description Photothermal therapy based on nanoparticles is a promising method for cancer treatment. However, there are still many limits in practical application. During photothermal therapy, improving therapeutic effect is contradictory to reducing overheating in healthy tissues. We should make the temperature distribution more uniform and reduce the damage of healthy tissue caused by overheating. In the present work, we develop a simple computational method to analyze the temperature distribution during photothermal therapy at three levels (nanoscale, micron scale, and millimeter scale), and investigate the effects of nanoparticle size, volume fraction, light intensity, and irradiation shape on temperature distribution. We find that it is difficult to achieve good therapeutic effect just by adjusting the volume fraction of nanoparticles and light intensity. To achieve good therapeutic effect, we propose a new irradiation shape, spot array light. This method can achieve a better temperature distribution by easily regulating the positions of spots for the tumor with a large aspect ratio or a small one. In addition, the method of irradiation with spot array light can better reduce the overheating at the bottom and top of the tumor than the full-coverage light or others such as ring light. This theoretical work presents a simple method to investigate the effects of irradiation shape on therapy and provides a far more controlled way to improve the efficacy of photothermal therapy.
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spelling pubmed-81241472021-05-17 A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale Jiang, Qingyun Li, Xinlei Yin, Chengping Materials (Basel) Article Photothermal therapy based on nanoparticles is a promising method for cancer treatment. However, there are still many limits in practical application. During photothermal therapy, improving therapeutic effect is contradictory to reducing overheating in healthy tissues. We should make the temperature distribution more uniform and reduce the damage of healthy tissue caused by overheating. In the present work, we develop a simple computational method to analyze the temperature distribution during photothermal therapy at three levels (nanoscale, micron scale, and millimeter scale), and investigate the effects of nanoparticle size, volume fraction, light intensity, and irradiation shape on temperature distribution. We find that it is difficult to achieve good therapeutic effect just by adjusting the volume fraction of nanoparticles and light intensity. To achieve good therapeutic effect, we propose a new irradiation shape, spot array light. This method can achieve a better temperature distribution by easily regulating the positions of spots for the tumor with a large aspect ratio or a small one. In addition, the method of irradiation with spot array light can better reduce the overheating at the bottom and top of the tumor than the full-coverage light or others such as ring light. This theoretical work presents a simple method to investigate the effects of irradiation shape on therapy and provides a far more controlled way to improve the efficacy of photothermal therapy. MDPI 2021-05-05 /pmc/articles/PMC8124147/ /pubmed/34063151 http://dx.doi.org/10.3390/ma14092407 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiang, Qingyun
Li, Xinlei
Yin, Chengping
A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale
title A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale
title_full A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale
title_fullStr A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale
title_full_unstemmed A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale
title_short A Study on Improving the Efficacy of Nanoparticle-Based Photothermal Therapy: From Nanoscale to Micron Scale to Millimeter Scale
title_sort study on improving the efficacy of nanoparticle-based photothermal therapy: from nanoscale to micron scale to millimeter scale
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124147/
https://www.ncbi.nlm.nih.gov/pubmed/34063151
http://dx.doi.org/10.3390/ma14092407
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