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ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis
COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the d...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124184/ https://www.ncbi.nlm.nih.gov/pubmed/33946649 http://dx.doi.org/10.3390/ijms22094691 |
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author | Poznyak, Anastasia V. Bezsonov, Evgeny E. Eid, Ali H. Popkova, Tatyana V. Nedosugova, Ludmila V. Starodubova, Antonina V. Orekhov, Alexander N. |
author_facet | Poznyak, Anastasia V. Bezsonov, Evgeny E. Eid, Ali H. Popkova, Tatyana V. Nedosugova, Ludmila V. Starodubova, Antonina V. Orekhov, Alexander N. |
author_sort | Poznyak, Anastasia V. |
collection | PubMed |
description | COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis. |
format | Online Article Text |
id | pubmed-8124184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81241842021-05-17 ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis Poznyak, Anastasia V. Bezsonov, Evgeny E. Eid, Ali H. Popkova, Tatyana V. Nedosugova, Ludmila V. Starodubova, Antonina V. Orekhov, Alexander N. Int J Mol Sci Review COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis. MDPI 2021-04-29 /pmc/articles/PMC8124184/ /pubmed/33946649 http://dx.doi.org/10.3390/ijms22094691 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Poznyak, Anastasia V. Bezsonov, Evgeny E. Eid, Ali H. Popkova, Tatyana V. Nedosugova, Ludmila V. Starodubova, Antonina V. Orekhov, Alexander N. ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis |
title | ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis |
title_full | ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis |
title_fullStr | ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis |
title_full_unstemmed | ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis |
title_short | ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis |
title_sort | ace2 is an adjacent element of atherosclerosis and covid-19 pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124184/ https://www.ncbi.nlm.nih.gov/pubmed/33946649 http://dx.doi.org/10.3390/ijms22094691 |
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