Cargando…

Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways

In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by mutations in pink1 or parkin. The Perk branch of the unfolded protein respon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Popovic, Rebeka, Celardo, Ivana, Yu, Yizhou, Costa, Ana C., Loh, Samantha H. Y., Martins, L. Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124185/ https://www.ncbi.nlm.nih.gov/pubmed/33925631 http://dx.doi.org/10.3390/ijms22094598

Ejemplares similares

Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease
por: Popovic, Rebeka, et al.
Publicado: (2023)

Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
por: Yu, Yizhou, et al.
Publicado: (2021)

Correction: Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
por: Yu, Yizhou, et al.
Publicado: (2021)

Upregulation of Tribbles decreases body weight and increases sleep duration
por: Popovic, Rebeka, et al.
Publicado: (2023)

dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective
por: Celardo, Ivana, et al.
Publicado: (2017)

Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin
por: Garrido-Maraver, Juan, et al.
Publicado: (2019)

Alzheimer’s and Parkinson’s Diseases Predict Different COVID-19 Outcomes: A UK Biobank Study
por: Yu, Yizhou, et al.
Publicado: (2021)

Links between air pollution and COVID-19 in England()
por: Travaglio, Marco, et al.
Publicado: (2021)

Increased cysteine metabolism in PINK1 models of Parkinson's disease
por: Travaglio, Marco, et al.
Publicado: (2023)

Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease
por: Lehmann, S, et al.
Publicado: (2016)

PERK Pathway and Neurodegenerative Disease: To Inhibit or to Activate?
por: Shacham, Talya, et al.
Publicado: (2021)

Glycosylation PERKs
por: Williams, Ruth
Publicado: (2007)

Unravelling mitochondrial pathways to Parkinson's disease
por: Celardo, I, et al.
Publicado: (2014)

PERK signaling pathway in bone metabolism: Friend or foe?
por: Guo, Jiachao, et al.
Publicado: (2021)

Mr. Charles Perks
Publicado: (1910)

Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?
por: Oliveira, Cláudia S., et al.
Publicado: (2020)

Interaction of Nck1 and PERK phosphorylated at Y(561) negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content
por: Yamani, Lama, et al.
Publicado: (2014)

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models
por: Ganz, Javier, et al.
Publicado: (2020)

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants
por: de Castro, I P, et al.
Publicado: (2013)

Activation of the PERK-ATF4 pathway promotes chemo-resistance in colon cancer cells
por: Shi, Zhong, et al.
Publicado: (2019)

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats
por: Xiong, Guirun, et al.
Publicado: (2019)

Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway
por: Wang, Wanzhen, et al.
Publicado: (2023)

Identification and Validation of Novel PERK Inhibitors
por: Wang, Qiantao, et al.
Publicado: (2014)

Fine‐tuning PERK signaling for neuroprotection
por: Halliday, Mark, et al.
Publicado: (2017)

Perking Up Strategies to Control Restenosis
por: Riascos-Bernal, Dario F.
Publicado: (2020)

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma
por: Pytel, Dariusz, et al.
Publicado: (2016)

Synergistic anticancer activity of cisplatin combined with tannic acid enhances apoptosis in lung cancer through the PERK-ATF4 pathway
por: Zheng, Xiang, et al.
Publicado: (2023)

Manganese activates autophagy to alleviate endoplasmic reticulum stress–induced apoptosis via PERK pathway
por: Liu, Chang, et al.
Publicado: (2019)

Transcriptome in Combination Proteome Unveils the Phenylpropane Pathway Involved in Garlic (Allium sativum) Greening
por: Wu, Jinxiang, et al.
Publicado: (2021)

Integrated Proteomic and Transcriptomic Investigation of the Acetaminophen Toxicity in Liver Microfluidic Biochip
por: Prot, Jean Matthieu, et al.
Publicado: (2011)

Activation of the Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor
por: Brady, Rhys D., et al.
Publicado: (2021)

CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response
por: Hong, Feng, et al.
Publicado: (2017)

Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation
por: Fujiki, Tamami, et al.
Publicado: (2019)

CTRP1 Attenuates Cerebral Ischemia/Reperfusion Injury via the PERK Signaling Pathway
por: Fei, Huizhi, et al.
Publicado: (2021)

NEFA Promotes Autophagosome Formation through Modulating PERK Signaling Pathway in Bovine Hepatocytes
por: Huang, Yan, et al.
Publicado: (2021)

Qingfei Tongluo Formula Mitigates Mycoplasma pneumoniae Infection via the PERK Signaling Pathway
por: Liu, Xiuxiu, et al.
Publicado: (2022)

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease
por: Celardo, I, et al.
Publicado: (2016)

PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway
por: Do, Mihyang, et al.
Publicado: (2022)

Commensal microbes and p53 in cancer progression
por: Celardo, Ivana, et al.
Publicado: (2020)

ER stress PERKs up an miRNA
por: Short, Ben
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vcno31toa3d79cgg74t8hk3iub