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ROR: Nuclear Receptor for Melatonin or Not?

Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action. Additionally, studies have illustrated that melatonin functions analogous to ROR li...

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Detalles Bibliográficos
Autores principales: Ma, Haozhen, Kang, Jun, Fan, Wenguo, He, Hongwen, Huang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124216/
https://www.ncbi.nlm.nih.gov/pubmed/34064466
http://dx.doi.org/10.3390/molecules26092693
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author Ma, Haozhen
Kang, Jun
Fan, Wenguo
He, Hongwen
Huang, Fang
author_facet Ma, Haozhen
Kang, Jun
Fan, Wenguo
He, Hongwen
Huang, Fang
author_sort Ma, Haozhen
collection PubMed
description Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action. Additionally, studies have illustrated that melatonin functions analogous to ROR ligands, thereby modulating the transcriptional activity of ROR. However, studies supporting these interactions have since been withdrawn. Furthermore, recent crystallographic evidence does not support the view that ROR is a nuclear receptor of melatonin. Some other studies have proposed that melatonin indirectly regulates ROR activity rather than directly binding to ROR. This review aims to delve into the complex relationship of the ROR receptor with melatonin in terms of its structure, expression, function, and mechanism. Thus, we provide the latest evidence and views on direct binding as well as indirect regulation of ROR by melatonin, dissecting both viewpoints in-depth to provide a more comprehensive perspective on this issue.
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spelling pubmed-81242162021-05-17 ROR: Nuclear Receptor for Melatonin or Not? Ma, Haozhen Kang, Jun Fan, Wenguo He, Hongwen Huang, Fang Molecules Review Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action. Additionally, studies have illustrated that melatonin functions analogous to ROR ligands, thereby modulating the transcriptional activity of ROR. However, studies supporting these interactions have since been withdrawn. Furthermore, recent crystallographic evidence does not support the view that ROR is a nuclear receptor of melatonin. Some other studies have proposed that melatonin indirectly regulates ROR activity rather than directly binding to ROR. This review aims to delve into the complex relationship of the ROR receptor with melatonin in terms of its structure, expression, function, and mechanism. Thus, we provide the latest evidence and views on direct binding as well as indirect regulation of ROR by melatonin, dissecting both viewpoints in-depth to provide a more comprehensive perspective on this issue. MDPI 2021-05-04 /pmc/articles/PMC8124216/ /pubmed/34064466 http://dx.doi.org/10.3390/molecules26092693 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Haozhen
Kang, Jun
Fan, Wenguo
He, Hongwen
Huang, Fang
ROR: Nuclear Receptor for Melatonin or Not?
title ROR: Nuclear Receptor for Melatonin or Not?
title_full ROR: Nuclear Receptor for Melatonin or Not?
title_fullStr ROR: Nuclear Receptor for Melatonin or Not?
title_full_unstemmed ROR: Nuclear Receptor for Melatonin or Not?
title_short ROR: Nuclear Receptor for Melatonin or Not?
title_sort ror: nuclear receptor for melatonin or not?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124216/
https://www.ncbi.nlm.nih.gov/pubmed/34064466
http://dx.doi.org/10.3390/molecules26092693
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