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Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure

The objective of this study is to assess the risk of newly acquired RNA detection-proven SARS-CoV-2 infection after previous SARS-CoV-2 infection. This is a prospective study conducted from March to September 2020 in Barcelona, Spain. Healthcare workers caring for SARS-CoV-2 infected patients were d...

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Autores principales: Sánchez-Montalvá, Adrián, Fernández-Naval, Candela, Antón, Andrés, Durà, Xavier, Vimes, Alba, Silgado, Aroa, Velásquez-Orozco, Fernando, Espinosa-Pereiro, Juan, Salvador, Fernando, Pumarola, Tomás, Almirante, Benito, Esperalba, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124281/
https://www.ncbi.nlm.nih.gov/pubmed/34064314
http://dx.doi.org/10.3390/jcm10091968
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author Sánchez-Montalvá, Adrián
Fernández-Naval, Candela
Antón, Andrés
Durà, Xavier
Vimes, Alba
Silgado, Aroa
Velásquez-Orozco, Fernando
Espinosa-Pereiro, Juan
Salvador, Fernando
Pumarola, Tomás
Almirante, Benito
Esperalba, Juliana
author_facet Sánchez-Montalvá, Adrián
Fernández-Naval, Candela
Antón, Andrés
Durà, Xavier
Vimes, Alba
Silgado, Aroa
Velásquez-Orozco, Fernando
Espinosa-Pereiro, Juan
Salvador, Fernando
Pumarola, Tomás
Almirante, Benito
Esperalba, Juliana
author_sort Sánchez-Montalvá, Adrián
collection PubMed
description The objective of this study is to assess the risk of newly acquired RNA detection-proven SARS-CoV-2 infection after previous SARS-CoV-2 infection. This is a prospective study conducted from March to September 2020 in Barcelona, Spain. Healthcare workers caring for SARS-CoV-2 infected patients were divided in two cohorts: (a) previously RNA-proven SARS-CoV-2 infected cohort with mild symptoms (IC) and (b) healthy cohort (HC). Weekly SARS-CoV-2 RNA detection assays from nasopharyngeal swabs were performed. Serology status was assessed at the beginning and at the end of the study. Twenty participants were included in each group. The median age was 30 (IQR 27–34.75) years, and 55% were female. The median time of follow up was 49 (IQR 49–51) days. Fifteen out of 246 (6%) nasopharyngeal swab samples were positive for SARS-CoV-2, all in the IC. The percentage of participants in the IC with a probable newly acquired SARS-CoV-2 RNA-proven infection was 20% (95% IC 5.7–43.6%) at the end of the 7-week follow up period. The incidence reinfection rate was 28.6 (95% IC 7.8–73.2) cases per 1000 person-week. Despite detectable IgG antibodies against SARS-CoV-2 participants highly exposed to SARS-CoV-2 may develop a newly acquired SARS-CoV-2 RNA detection episode during the first months after the initial infection.
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spelling pubmed-81242812021-05-17 Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure Sánchez-Montalvá, Adrián Fernández-Naval, Candela Antón, Andrés Durà, Xavier Vimes, Alba Silgado, Aroa Velásquez-Orozco, Fernando Espinosa-Pereiro, Juan Salvador, Fernando Pumarola, Tomás Almirante, Benito Esperalba, Juliana J Clin Med Article The objective of this study is to assess the risk of newly acquired RNA detection-proven SARS-CoV-2 infection after previous SARS-CoV-2 infection. This is a prospective study conducted from March to September 2020 in Barcelona, Spain. Healthcare workers caring for SARS-CoV-2 infected patients were divided in two cohorts: (a) previously RNA-proven SARS-CoV-2 infected cohort with mild symptoms (IC) and (b) healthy cohort (HC). Weekly SARS-CoV-2 RNA detection assays from nasopharyngeal swabs were performed. Serology status was assessed at the beginning and at the end of the study. Twenty participants were included in each group. The median age was 30 (IQR 27–34.75) years, and 55% were female. The median time of follow up was 49 (IQR 49–51) days. Fifteen out of 246 (6%) nasopharyngeal swab samples were positive for SARS-CoV-2, all in the IC. The percentage of participants in the IC with a probable newly acquired SARS-CoV-2 RNA-proven infection was 20% (95% IC 5.7–43.6%) at the end of the 7-week follow up period. The incidence reinfection rate was 28.6 (95% IC 7.8–73.2) cases per 1000 person-week. Despite detectable IgG antibodies against SARS-CoV-2 participants highly exposed to SARS-CoV-2 may develop a newly acquired SARS-CoV-2 RNA detection episode during the first months after the initial infection. MDPI 2021-05-04 /pmc/articles/PMC8124281/ /pubmed/34064314 http://dx.doi.org/10.3390/jcm10091968 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-Montalvá, Adrián
Fernández-Naval, Candela
Antón, Andrés
Durà, Xavier
Vimes, Alba
Silgado, Aroa
Velásquez-Orozco, Fernando
Espinosa-Pereiro, Juan
Salvador, Fernando
Pumarola, Tomás
Almirante, Benito
Esperalba, Juliana
Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
title Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
title_full Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
title_fullStr Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
title_full_unstemmed Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
title_short Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
title_sort risk of sars-cov-2 infection in previously infected and non-infected cohorts of health workers at high risk of exposure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124281/
https://www.ncbi.nlm.nih.gov/pubmed/34064314
http://dx.doi.org/10.3390/jcm10091968
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