Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism

Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for th...

Descripción completa

Detalles Bibliográficos
Autores principales: Mochizuki-Kashio, Makiko, Shiozaki, Hiroko, Suda, Toshio, Nakamura-Ishizu, Ayako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124492/
https://www.ncbi.nlm.nih.gov/pubmed/33924874
http://dx.doi.org/10.3390/ijms22094627
_version_ 1783693220976263168
author Mochizuki-Kashio, Makiko
Shiozaki, Hiroko
Suda, Toshio
Nakamura-Ishizu, Ayako
author_facet Mochizuki-Kashio, Makiko
Shiozaki, Hiroko
Suda, Toshio
Nakamura-Ishizu, Ayako
author_sort Mochizuki-Kashio, Makiko
collection PubMed
description Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis.
format Online
Article
Text
id pubmed-8124492
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81244922021-05-17 Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism Mochizuki-Kashio, Makiko Shiozaki, Hiroko Suda, Toshio Nakamura-Ishizu, Ayako Int J Mol Sci Review Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis. MDPI 2021-04-28 /pmc/articles/PMC8124492/ /pubmed/33924874 http://dx.doi.org/10.3390/ijms22094627 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mochizuki-Kashio, Makiko
Shiozaki, Hiroko
Suda, Toshio
Nakamura-Ishizu, Ayako
Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
title Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
title_full Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
title_fullStr Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
title_full_unstemmed Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
title_short Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
title_sort mitochondria turnover and lysosomal function in hematopoietic stem cell metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124492/
https://www.ncbi.nlm.nih.gov/pubmed/33924874
http://dx.doi.org/10.3390/ijms22094627
work_keys_str_mv AT mochizukikashiomakiko mitochondriaturnoverandlysosomalfunctioninhematopoieticstemcellmetabolism
AT shiozakihiroko mitochondriaturnoverandlysosomalfunctioninhematopoieticstemcellmetabolism
AT sudatoshio mitochondriaturnoverandlysosomalfunctioninhematopoieticstemcellmetabolism
AT nakamuraishizuayako mitochondriaturnoverandlysosomalfunctioninhematopoieticstemcellmetabolism

Ejemplares similares