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Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer

Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic fibrosis is frequently present in chronic pancreatitis (CP) and pancreatic cancer (PC). Clinically, pancreatic fibrosis i...

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Detalles Bibliográficos
Autores principales: Huang, Can, Iovanna, Juan, Santofimia-Castaño, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124541/
https://www.ncbi.nlm.nih.gov/pubmed/34067040
http://dx.doi.org/10.3390/ijms22094970
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author Huang, Can
Iovanna, Juan
Santofimia-Castaño, Patricia
author_facet Huang, Can
Iovanna, Juan
Santofimia-Castaño, Patricia
author_sort Huang, Can
collection PubMed
description Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic fibrosis is frequently present in chronic pancreatitis (CP) and pancreatic cancer (PC). Clinically, pancreatic fibrosis is a pathological feature of pancreatitis and pancreatic cancer. However, many new studies have found that pancreatic fibrosis is involved in the transformation from pancreatitis to pancreatic cancer. Thus, the role of fibrosis in the crosstalk between pancreatitis and pancreatic cancer is critical and still elusive; therefore, it deserves more attention. Here, we review the development of pancreatic fibrosis in inflammation and cancer, and we discuss the therapeutic strategies for alleviating pancreatic fibrosis. We further propose that cellular stress response might be a key driver that links fibrosis to cancer initiation and progression. Therefore, targeting stress proteins, such as nuclear protein 1 (NUPR1), could be an interesting strategy for pancreatic fibrosis and PC treatment.
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spelling pubmed-81245412021-05-17 Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer Huang, Can Iovanna, Juan Santofimia-Castaño, Patricia Int J Mol Sci Review Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic fibrosis is frequently present in chronic pancreatitis (CP) and pancreatic cancer (PC). Clinically, pancreatic fibrosis is a pathological feature of pancreatitis and pancreatic cancer. However, many new studies have found that pancreatic fibrosis is involved in the transformation from pancreatitis to pancreatic cancer. Thus, the role of fibrosis in the crosstalk between pancreatitis and pancreatic cancer is critical and still elusive; therefore, it deserves more attention. Here, we review the development of pancreatic fibrosis in inflammation and cancer, and we discuss the therapeutic strategies for alleviating pancreatic fibrosis. We further propose that cellular stress response might be a key driver that links fibrosis to cancer initiation and progression. Therefore, targeting stress proteins, such as nuclear protein 1 (NUPR1), could be an interesting strategy for pancreatic fibrosis and PC treatment. MDPI 2021-05-07 /pmc/articles/PMC8124541/ /pubmed/34067040 http://dx.doi.org/10.3390/ijms22094970 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Can
Iovanna, Juan
Santofimia-Castaño, Patricia
Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
title Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
title_full Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
title_fullStr Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
title_full_unstemmed Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
title_short Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer
title_sort targeting fibrosis: the bridge that connects pancreatitis and pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124541/
https://www.ncbi.nlm.nih.gov/pubmed/34067040
http://dx.doi.org/10.3390/ijms22094970
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