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Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier

The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a cri...

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Detalles Bibliográficos
Autores principales: Danis, Judit, Mellett, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124564/
https://www.ncbi.nlm.nih.gov/pubmed/33925158
http://dx.doi.org/10.3390/ijms22094677
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author Danis, Judit
Mellett, Mark
author_facet Danis, Judit
Mellett, Mark
author_sort Danis, Judit
collection PubMed
description The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease.
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spelling pubmed-81245642021-05-17 Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier Danis, Judit Mellett, Mark Int J Mol Sci Review The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease. MDPI 2021-04-28 /pmc/articles/PMC8124564/ /pubmed/33925158 http://dx.doi.org/10.3390/ijms22094677 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Danis, Judit
Mellett, Mark
Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
title Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
title_full Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
title_fullStr Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
title_full_unstemmed Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
title_short Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
title_sort nod-like receptors in host defence and disease at the epidermal barrier
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124564/
https://www.ncbi.nlm.nih.gov/pubmed/33925158
http://dx.doi.org/10.3390/ijms22094677
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