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Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a cri...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124564/ https://www.ncbi.nlm.nih.gov/pubmed/33925158 http://dx.doi.org/10.3390/ijms22094677 |
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author | Danis, Judit Mellett, Mark |
author_facet | Danis, Judit Mellett, Mark |
author_sort | Danis, Judit |
collection | PubMed |
description | The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease. |
format | Online Article Text |
id | pubmed-8124564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81245642021-05-17 Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier Danis, Judit Mellett, Mark Int J Mol Sci Review The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease. MDPI 2021-04-28 /pmc/articles/PMC8124564/ /pubmed/33925158 http://dx.doi.org/10.3390/ijms22094677 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Danis, Judit Mellett, Mark Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
title | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
title_full | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
title_fullStr | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
title_full_unstemmed | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
title_short | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
title_sort | nod-like receptors in host defence and disease at the epidermal barrier |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124564/ https://www.ncbi.nlm.nih.gov/pubmed/33925158 http://dx.doi.org/10.3390/ijms22094677 |
work_keys_str_mv | AT danisjudit nodlikereceptorsinhostdefenceanddiseaseattheepidermalbarrier AT mellettmark nodlikereceptorsinhostdefenceanddiseaseattheepidermalbarrier |