The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota deter...

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Autores principales: Suslov, Andrey V., Chairkina, Elizaveta, Shepetovskaya, Maria D., Suslova, Irina S., Khotina, Victoria A., Kirichenko, Tatiana V., Postnov, Anton Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124579/
https://www.ncbi.nlm.nih.gov/pubmed/34066528
http://dx.doi.org/10.3390/jcm10091995
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author Suslov, Andrey V.
Chairkina, Elizaveta
Shepetovskaya, Maria D.
Suslova, Irina S.
Khotina, Victoria A.
Kirichenko, Tatiana V.
Postnov, Anton Y.
author_facet Suslov, Andrey V.
Chairkina, Elizaveta
Shepetovskaya, Maria D.
Suslova, Irina S.
Khotina, Victoria A.
Kirichenko, Tatiana V.
Postnov, Anton Y.
author_sort Suslov, Andrey V.
collection PubMed
description Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota determines the level of activation of the hypothalamic–pituitary system. In particular, the intestinal microbiota is an important source of neuroimmune mediators in the pathogenesis of cardiovascular disease. This review reflects the current state of publications in PubMed and Scopus databases until December 2020 on the mechanisms of formation and participation of neuroimmune mediators associated with gut microbiota in the development of cardiovascular disease.
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spelling pubmed-81245792021-05-17 The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease Suslov, Andrey V. Chairkina, Elizaveta Shepetovskaya, Maria D. Suslova, Irina S. Khotina, Victoria A. Kirichenko, Tatiana V. Postnov, Anton Y. J Clin Med Review Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota determines the level of activation of the hypothalamic–pituitary system. In particular, the intestinal microbiota is an important source of neuroimmune mediators in the pathogenesis of cardiovascular disease. This review reflects the current state of publications in PubMed and Scopus databases until December 2020 on the mechanisms of formation and participation of neuroimmune mediators associated with gut microbiota in the development of cardiovascular disease. MDPI 2021-05-06 /pmc/articles/PMC8124579/ /pubmed/34066528 http://dx.doi.org/10.3390/jcm10091995 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suslov, Andrey V.
Chairkina, Elizaveta
Shepetovskaya, Maria D.
Suslova, Irina S.
Khotina, Victoria A.
Kirichenko, Tatiana V.
Postnov, Anton Y.
The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease
title The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease
title_full The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease
title_fullStr The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease
title_full_unstemmed The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease
title_short The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease
title_sort neuroimmune role of intestinal microbiota in the pathogenesis of cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124579/
https://www.ncbi.nlm.nih.gov/pubmed/34066528
http://dx.doi.org/10.3390/jcm10091995
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