Cargando…

Targeting CDK9 for Anti-Cancer Therapeutics

SIMPLE SUMMARY: CDK9, in combination with Cyclin T1, is one of the major regulators of RNA Polymerase II mediated productive transcription of critical genes in any cell. The activity of CDK9 is significantly up-regulated in a wide variety of cancer entities, to aid in the overexpression of genes res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mandal, Ranadip, Becker, Sven, Strebhardt, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124690/ https://www.ncbi.nlm.nih.gov/pubmed/34062779 http://dx.doi.org/10.3390/cancers13092181

Ejemplares similares

The role of caspase-8 in the tumor microenvironment of ovarian cancer
por: Kostova, Izabela, et al.
Publicado: (2020)

Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy
por: Fleischmann, Maximilian, et al.
Publicado: (2022)

The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer
por: Mandal, Ranadip, et al.
Publicado: (2022)

Correction: The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer
por: Mandal, Ranadip, et al.
Publicado: (2023)

Modelling the Functions of Polo-Like Kinases in Mice and Their Applications as Cancer Targets with a Special Focus on Ovarian Cancer
por: Kressin, Monika, et al.
Publicado: (2021)

The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression
por: Rödel, Franz, et al.
Publicado: (2020)

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8
por: Helmke, Christina, et al.
Publicado: (2016)

Targeting CDK9 for the Treatment of Glioblastoma
por: Ranjan, Alice, et al.
Publicado: (2021)

Targeting CDK9 for treatment of colorectal cancer
por: Rahaman, Muhammed H., et al.
Publicado: (2019)

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells
por: Raab, Monika, et al.
Publicado: (2021)

The Role of DAPK1 in the Cell Cycle Regulation of Cervical Cancer Cells and in Response to Topotecan
por: Gasimli, Khayal, et al.
Publicado: (2022)

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma
por: Ma, Hangzhan, et al.
Publicado: (2018)

Sequential Targeting of PLK1 and PARP1 Reverses the Resistance to PARP Inhibitors and Enhances Platin-Based Chemotherapy in BRCA-Deficient High-Grade Serous Ovarian Cancer with KRAS Amplification
por: Gasimli, Khayal, et al.
Publicado: (2022)

Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067
por: Shen, Shen, et al.
Publicado: (2020)

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis
por: Hellvard, Annelie, et al.
Publicado: (2016)

Targeting CDK9: A novel biomarker in the treatment of endometrial cancer
por: He, Shasha, et al.
Publicado: (2020)

CDK8-Novel Therapeutic Opportunities
por: Menzl, Ingeborg, et al.
Publicado: (2019)

CDK9 inhibitors in acute myeloid leukemia
por: Boffo, Silvia, et al.
Publicado: (2018)

Identification of a novel CDK9 inhibitor targeting the intramolecular hidden cavity of CDK9 induced by Tat binding
por: Asamitsu, Kaori, et al.
Publicado: (2022)

Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments
por: Xiao, Lanshu, et al.
Publicado: (2023)

CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents
por: Anshabo, Abel Tesfaye, et al.
Publicado: (2021)

Targeting CDK1 in cancer: mechanisms and implications
por: Wang, Qiushi, et al.
Publicado: (2023)

Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation
por: Nekhai, Sergei, et al.
Publicado: (2014)

CDK9 keeps RNA polymerase II on track
por: Egloff, Sylvain
Publicado: (2021)

Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
por: Kryštof, Vladimír, et al.
Publicado: (2012)

Biological functions of CDK5 and potential CDK5 targeted clinical treatments
por: Shupp, Alison, et al.
Publicado: (2017)

Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability
por: Raab, Monika, et al.
Publicado: (2019)

Development of CDK inhibitors as cancer therapeutics
por: Lane, D
Publicado: (2005)

Therapeutic potential of CDK11 in cancer
por: Blazek, Dalibor
Publicado: (2023)

CDK/CCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity
por: Bonelli, Patrizia, et al.
Publicado: (2014)

Current Therapeutic Progress of CDK4/6 Inhibitors in Breast Cancer
por: Wu, Yanmei, et al.
Publicado: (2020)

Anti-leukemic effect of CDK9 inhibition in T-cell prolymphocytic leukemia
por: Johansson, Patricia, et al.
Publicado: (2020)

The Prognostic Role of CDK9 in Bladder Cancer
por: Borowczak, Jędrzej, et al.
Publicado: (2022)

Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma
por: Tong, Zhimin, et al.
Publicado: (2019)

CDK1 serves as a novel therapeutic target for endometrioid endometrial cancer
por: Ying, Xue, et al.
Publicado: (2021)

CDK12 and PAK2 as novel therapeutic targets for human gastric cancer
por: Liu, Hui, et al.
Publicado: (2020)

Future Aspects of CDK5 in Prostate Cancer: From Pathogenesis to Therapeutic Implications
por: Oner, Muhammet, et al.
Publicado: (2019)

CCR9 in cancer: oncogenic role and therapeutic targeting
por: Tu, Zhenbo, et al.
Publicado: (2016)

CDK9 inhibition strategy defines distinct sets of target genes
por: Garriga, Judit, et al.
Publicado: (2014)

Is CDK9 a promising target for both primary and metastatic osteosarcoma?
por: Qin, Jiang-Jiang
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9d9l8c7qtpp0d8il9vp057igvu