SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functio...

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Detalles Bibliográficos
Autores principales: Li, Licen, Deng, Chu-Xia, Chen, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124743/
https://www.ncbi.nlm.nih.gov/pubmed/33946224
http://dx.doi.org/10.3390/ijms22094760
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author Li, Licen
Deng, Chu-Xia
Chen, Qiang
author_facet Li, Licen
Deng, Chu-Xia
Chen, Qiang
author_sort Li, Licen
collection PubMed
description Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.
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spelling pubmed-81247432021-05-17 SRC-3, a Steroid Receptor Coactivator: Implication in Cancer Li, Licen Deng, Chu-Xia Chen, Qiang Int J Mol Sci Review Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy. MDPI 2021-04-30 /pmc/articles/PMC8124743/ /pubmed/33946224 http://dx.doi.org/10.3390/ijms22094760 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Licen
Deng, Chu-Xia
Chen, Qiang
SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
title SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
title_full SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
title_fullStr SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
title_full_unstemmed SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
title_short SRC-3, a Steroid Receptor Coactivator: Implication in Cancer
title_sort src-3, a steroid receptor coactivator: implication in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124743/
https://www.ncbi.nlm.nih.gov/pubmed/33946224
http://dx.doi.org/10.3390/ijms22094760
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AT dengchuxia src3asteroidreceptorcoactivatorimplicationincancer
AT chenqiang src3asteroidreceptorcoactivatorimplicationincancer

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