Role of ABCA7 in Human Health and in Alzheimer’s Disease

Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzhe...

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Detalles Bibliográficos
Autores principales: Dib, Shiraz, Pahnke, Jens, Gosselet, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124837/
https://www.ncbi.nlm.nih.gov/pubmed/33925691
http://dx.doi.org/10.3390/ijms22094603
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author Dib, Shiraz
Pahnke, Jens
Gosselet, Fabien
author_facet Dib, Shiraz
Pahnke, Jens
Gosselet, Fabien
author_sort Dib, Shiraz
collection PubMed
description Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.
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spelling pubmed-81248372021-05-17 Role of ABCA7 in Human Health and in Alzheimer’s Disease Dib, Shiraz Pahnke, Jens Gosselet, Fabien Int J Mol Sci Review Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development. MDPI 2021-04-27 /pmc/articles/PMC8124837/ /pubmed/33925691 http://dx.doi.org/10.3390/ijms22094603 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dib, Shiraz
Pahnke, Jens
Gosselet, Fabien
Role of ABCA7 in Human Health and in Alzheimer’s Disease
title Role of ABCA7 in Human Health and in Alzheimer’s Disease
title_full Role of ABCA7 in Human Health and in Alzheimer’s Disease
title_fullStr Role of ABCA7 in Human Health and in Alzheimer’s Disease
title_full_unstemmed Role of ABCA7 in Human Health and in Alzheimer’s Disease
title_short Role of ABCA7 in Human Health and in Alzheimer’s Disease
title_sort role of abca7 in human health and in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124837/
https://www.ncbi.nlm.nih.gov/pubmed/33925691
http://dx.doi.org/10.3390/ijms22094603
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