Cargando…

The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling

Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the p...

Descripción completa

Detalles Bibliográficos
Autores principales: Adamcova, Michaela, Kawano, Ippei, Simko, Fedor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124994/
https://www.ncbi.nlm.nih.gov/pubmed/33946230
http://dx.doi.org/10.3390/ijms22094762
_version_ 1783693370438189056
author Adamcova, Michaela
Kawano, Ippei
Simko, Fedor
author_facet Adamcova, Michaela
Kawano, Ippei
Simko, Fedor
author_sort Adamcova, Michaela
collection PubMed
description Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets
format Online
Article
Text
id pubmed-8124994
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81249942021-05-17 The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling Adamcova, Michaela Kawano, Ippei Simko, Fedor Int J Mol Sci Review Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets MDPI 2021-04-30 /pmc/articles/PMC8124994/ /pubmed/33946230 http://dx.doi.org/10.3390/ijms22094762 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Adamcova, Michaela
Kawano, Ippei
Simko, Fedor
The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
title The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
title_full The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
title_fullStr The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
title_full_unstemmed The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
title_short The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
title_sort impact of micrornas in renin–angiotensin-system-induced cardiac remodelling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124994/
https://www.ncbi.nlm.nih.gov/pubmed/33946230
http://dx.doi.org/10.3390/ijms22094762
work_keys_str_mv AT adamcovamichaela theimpactofmicrornasinreninangiotensinsysteminducedcardiacremodelling
AT kawanoippei theimpactofmicrornasinreninangiotensinsysteminducedcardiacremodelling
AT simkofedor theimpactofmicrornasinreninangiotensinsysteminducedcardiacremodelling
AT adamcovamichaela impactofmicrornasinreninangiotensinsysteminducedcardiacremodelling
AT kawanoippei impactofmicrornasinreninangiotensinsysteminducedcardiacremodelling
AT simkofedor impactofmicrornasinreninangiotensinsysteminducedcardiacremodelling