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The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124994/ https://www.ncbi.nlm.nih.gov/pubmed/33946230 http://dx.doi.org/10.3390/ijms22094762 |
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author | Adamcova, Michaela Kawano, Ippei Simko, Fedor |
author_facet | Adamcova, Michaela Kawano, Ippei Simko, Fedor |
author_sort | Adamcova, Michaela |
collection | PubMed |
description | Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets |
format | Online Article Text |
id | pubmed-8124994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81249942021-05-17 The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling Adamcova, Michaela Kawano, Ippei Simko, Fedor Int J Mol Sci Review Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets MDPI 2021-04-30 /pmc/articles/PMC8124994/ /pubmed/33946230 http://dx.doi.org/10.3390/ijms22094762 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Adamcova, Michaela Kawano, Ippei Simko, Fedor The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling |
title | The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling |
title_full | The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling |
title_fullStr | The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling |
title_full_unstemmed | The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling |
title_short | The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling |
title_sort | impact of micrornas in renin–angiotensin-system-induced cardiac remodelling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124994/ https://www.ncbi.nlm.nih.gov/pubmed/33946230 http://dx.doi.org/10.3390/ijms22094762 |
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