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Low-Temperature Photothermal Therapy: Strategies and Applications

Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the ef...

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Detalles Bibliográficos
Autores principales: Yi, Xiulin, Duan, Qiu-Yi, Wu, Fu-Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125200/
https://www.ncbi.nlm.nih.gov/pubmed/34041494
http://dx.doi.org/10.34133/2021/9816594
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author Yi, Xiulin
Duan, Qiu-Yi
Wu, Fu-Gen
author_facet Yi, Xiulin
Duan, Qiu-Yi
Wu, Fu-Gen
author_sort Yi, Xiulin
collection PubMed
description Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments.
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spelling pubmed-81252002021-05-25 Low-Temperature Photothermal Therapy: Strategies and Applications Yi, Xiulin Duan, Qiu-Yi Wu, Fu-Gen Research (Wash D C) Review Article Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in the biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells to develop thermal resistance, and thus, the efficacy of PTT may be dramatically decreased. In the meantime, the uncontrollable diffusion of heat can pose a threat to the surrounding healthy tissues. Recently, low-temperature PTT (also known as mild PTT or mild-temperature PTT) has demonstrated its remarkable capacity of conquering these obstacles and has shown excellent performance in bacterial elimination, wound healing, and cancer treatments. Herein, we summarize the recently proposed strategies for achieving low-temperature PTT based on nanomaterials and introduce the synthesis, characteristics, and applications of these nanoplatforms. Additionally, the combination of PTT and other therapeutic modalities for defeating cancers and the synergistic cancer therapeutic effect of the combined treatments are discussed. Finally, the current limitations and future directions are proposed for inspiring more researchers to make contributions to promoting low-temperature PTT toward more successful preclinical and clinical disease treatments. AAAS 2021-05-07 /pmc/articles/PMC8125200/ /pubmed/34041494 http://dx.doi.org/10.34133/2021/9816594 Text en Copyright © 2021 Xiulin Yi et al. https://creativecommons.org/licenses/by/4.0/Exclusive Licensee Science and Technology Review Publishing House. Distributed under a Creative Commons Attribution License (CC BY 4.0).
spellingShingle Review Article
Yi, Xiulin
Duan, Qiu-Yi
Wu, Fu-Gen
Low-Temperature Photothermal Therapy: Strategies and Applications
title Low-Temperature Photothermal Therapy: Strategies and Applications
title_full Low-Temperature Photothermal Therapy: Strategies and Applications
title_fullStr Low-Temperature Photothermal Therapy: Strategies and Applications
title_full_unstemmed Low-Temperature Photothermal Therapy: Strategies and Applications
title_short Low-Temperature Photothermal Therapy: Strategies and Applications
title_sort low-temperature photothermal therapy: strategies and applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125200/
https://www.ncbi.nlm.nih.gov/pubmed/34041494
http://dx.doi.org/10.34133/2021/9816594
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