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Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients s...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125207/ https://www.ncbi.nlm.nih.gov/pubmed/34064307 http://dx.doi.org/10.3390/jcm10091967 |
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author | Parasiliti-Caprino, Mirko Obert, Chiara Lopez, Chiara Bollati, Martina Bioletto, Fabio Bima, Chiara Egalini, Filippo Berton, Alessandro Maria Prencipe, Nunzia Settanni, Fabio Gasco, Valentina Mengozzi, Giulio Ghigo, Ezio Maccario, Mauro |
author_facet | Parasiliti-Caprino, Mirko Obert, Chiara Lopez, Chiara Bollati, Martina Bioletto, Fabio Bima, Chiara Egalini, Filippo Berton, Alessandro Maria Prencipe, Nunzia Settanni, Fabio Gasco, Valentina Mengozzi, Giulio Ghigo, Ezio Maccario, Mauro |
author_sort | Parasiliti-Caprino, Mirko |
collection | PubMed |
description | No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation of urine metanephrines at the City of Health and Science University Hospital of Turin between 2007 and 2015, mainly for investigating the suspicion of secondary hypertension or the secretion of an adrenal lesion. The univariate analysis showed associations between metanephrines and cardiometabolic variables/parameters, particularly considering noradrenaline metabolite. At univariate regression, normetanephrine was associated with hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.11–1.25; p < 0.001) and metabolic syndrome (OR = 1.11, 95% CI 1.03–1.20; p = 0.004), while metanephrine was associated with hypertensive cardiomyopathy (OR = 1.23, 95% CI 1.06–1.43; p = 0.006) and microalbuminuria (OR = 1.30, 95% CI 1.03–1.60; p = 0.018). At multivariate regression, considering all major cardiovascular risk factors as possible confounders, normetanephrine retained a significant association with hypertensive cardiomyopathy (OR = 1.14, 95% CI 1.07–1.22; p < 0.001) and metabolic syndrome (OR = 1.10, 95% CI 1.02–1.19; p = 0.017). Moreover, metanephrine retained a significant association with the presence of hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.01–1.41; p = 0.049) and microalbuminuria (OR = 1.34, 95% CI 1.03–1.69; p = 0.019). The study showed a strong relationship between metanephrines and cardiovascular complications/metabolic alterations. Individuals with high levels of these indirect markers of sympathetic activity should be carefully monitored, and they may benefit from an aggressive treatment to reduce the cardiometabolic risk. |
format | Online Article Text |
id | pubmed-8125207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81252072021-05-17 Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study Parasiliti-Caprino, Mirko Obert, Chiara Lopez, Chiara Bollati, Martina Bioletto, Fabio Bima, Chiara Egalini, Filippo Berton, Alessandro Maria Prencipe, Nunzia Settanni, Fabio Gasco, Valentina Mengozzi, Giulio Ghigo, Ezio Maccario, Mauro J Clin Med Article No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation of urine metanephrines at the City of Health and Science University Hospital of Turin between 2007 and 2015, mainly for investigating the suspicion of secondary hypertension or the secretion of an adrenal lesion. The univariate analysis showed associations between metanephrines and cardiometabolic variables/parameters, particularly considering noradrenaline metabolite. At univariate regression, normetanephrine was associated with hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.11–1.25; p < 0.001) and metabolic syndrome (OR = 1.11, 95% CI 1.03–1.20; p = 0.004), while metanephrine was associated with hypertensive cardiomyopathy (OR = 1.23, 95% CI 1.06–1.43; p = 0.006) and microalbuminuria (OR = 1.30, 95% CI 1.03–1.60; p = 0.018). At multivariate regression, considering all major cardiovascular risk factors as possible confounders, normetanephrine retained a significant association with hypertensive cardiomyopathy (OR = 1.14, 95% CI 1.07–1.22; p < 0.001) and metabolic syndrome (OR = 1.10, 95% CI 1.02–1.19; p = 0.017). Moreover, metanephrine retained a significant association with the presence of hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.01–1.41; p = 0.049) and microalbuminuria (OR = 1.34, 95% CI 1.03–1.69; p = 0.019). The study showed a strong relationship between metanephrines and cardiovascular complications/metabolic alterations. Individuals with high levels of these indirect markers of sympathetic activity should be carefully monitored, and they may benefit from an aggressive treatment to reduce the cardiometabolic risk. MDPI 2021-05-04 /pmc/articles/PMC8125207/ /pubmed/34064307 http://dx.doi.org/10.3390/jcm10091967 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Parasiliti-Caprino, Mirko Obert, Chiara Lopez, Chiara Bollati, Martina Bioletto, Fabio Bima, Chiara Egalini, Filippo Berton, Alessandro Maria Prencipe, Nunzia Settanni, Fabio Gasco, Valentina Mengozzi, Giulio Ghigo, Ezio Maccario, Mauro Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study |
title | Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study |
title_full | Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study |
title_fullStr | Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study |
title_full_unstemmed | Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study |
title_short | Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study |
title_sort | association of urine metanephrine levels with cardiometabolic risk: an observational retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125207/ https://www.ncbi.nlm.nih.gov/pubmed/34064307 http://dx.doi.org/10.3390/jcm10091967 |
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