Cargando…

Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study

No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients s...

Descripción completa

Detalles Bibliográficos
Autores principales: Parasiliti-Caprino, Mirko, Obert, Chiara, Lopez, Chiara, Bollati, Martina, Bioletto, Fabio, Bima, Chiara, Egalini, Filippo, Berton, Alessandro Maria, Prencipe, Nunzia, Settanni, Fabio, Gasco, Valentina, Mengozzi, Giulio, Ghigo, Ezio, Maccario, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125207/
https://www.ncbi.nlm.nih.gov/pubmed/34064307
http://dx.doi.org/10.3390/jcm10091967
_version_ 1783693432151080960
author Parasiliti-Caprino, Mirko
Obert, Chiara
Lopez, Chiara
Bollati, Martina
Bioletto, Fabio
Bima, Chiara
Egalini, Filippo
Berton, Alessandro Maria
Prencipe, Nunzia
Settanni, Fabio
Gasco, Valentina
Mengozzi, Giulio
Ghigo, Ezio
Maccario, Mauro
author_facet Parasiliti-Caprino, Mirko
Obert, Chiara
Lopez, Chiara
Bollati, Martina
Bioletto, Fabio
Bima, Chiara
Egalini, Filippo
Berton, Alessandro Maria
Prencipe, Nunzia
Settanni, Fabio
Gasco, Valentina
Mengozzi, Giulio
Ghigo, Ezio
Maccario, Mauro
author_sort Parasiliti-Caprino, Mirko
collection PubMed
description No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation of urine metanephrines at the City of Health and Science University Hospital of Turin between 2007 and 2015, mainly for investigating the suspicion of secondary hypertension or the secretion of an adrenal lesion. The univariate analysis showed associations between metanephrines and cardiometabolic variables/parameters, particularly considering noradrenaline metabolite. At univariate regression, normetanephrine was associated with hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.11–1.25; p < 0.001) and metabolic syndrome (OR = 1.11, 95% CI 1.03–1.20; p = 0.004), while metanephrine was associated with hypertensive cardiomyopathy (OR = 1.23, 95% CI 1.06–1.43; p = 0.006) and microalbuminuria (OR = 1.30, 95% CI 1.03–1.60; p = 0.018). At multivariate regression, considering all major cardiovascular risk factors as possible confounders, normetanephrine retained a significant association with hypertensive cardiomyopathy (OR = 1.14, 95% CI 1.07–1.22; p < 0.001) and metabolic syndrome (OR = 1.10, 95% CI 1.02–1.19; p = 0.017). Moreover, metanephrine retained a significant association with the presence of hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.01–1.41; p = 0.049) and microalbuminuria (OR = 1.34, 95% CI 1.03–1.69; p = 0.019). The study showed a strong relationship between metanephrines and cardiovascular complications/metabolic alterations. Individuals with high levels of these indirect markers of sympathetic activity should be carefully monitored, and they may benefit from an aggressive treatment to reduce the cardiometabolic risk.
format Online
Article
Text
id pubmed-8125207
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81252072021-05-17 Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study Parasiliti-Caprino, Mirko Obert, Chiara Lopez, Chiara Bollati, Martina Bioletto, Fabio Bima, Chiara Egalini, Filippo Berton, Alessandro Maria Prencipe, Nunzia Settanni, Fabio Gasco, Valentina Mengozzi, Giulio Ghigo, Ezio Maccario, Mauro J Clin Med Article No research has explored the role of catecholamine metabolites in the stratification of cardiovascular risk. We aimed to evaluate the relationship between urine metanephrines and cardiometabolic risk/complications. In this retrospective cross-sectional study, we collected the data of 1374 patients submitted to the evaluation of urine metanephrines at the City of Health and Science University Hospital of Turin between 2007 and 2015, mainly for investigating the suspicion of secondary hypertension or the secretion of an adrenal lesion. The univariate analysis showed associations between metanephrines and cardiometabolic variables/parameters, particularly considering noradrenaline metabolite. At univariate regression, normetanephrine was associated with hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.11–1.25; p < 0.001) and metabolic syndrome (OR = 1.11, 95% CI 1.03–1.20; p = 0.004), while metanephrine was associated with hypertensive cardiomyopathy (OR = 1.23, 95% CI 1.06–1.43; p = 0.006) and microalbuminuria (OR = 1.30, 95% CI 1.03–1.60; p = 0.018). At multivariate regression, considering all major cardiovascular risk factors as possible confounders, normetanephrine retained a significant association with hypertensive cardiomyopathy (OR = 1.14, 95% CI 1.07–1.22; p < 0.001) and metabolic syndrome (OR = 1.10, 95% CI 1.02–1.19; p = 0.017). Moreover, metanephrine retained a significant association with the presence of hypertensive cardiomyopathy (OR = 1.18, 95% CI 1.01–1.41; p = 0.049) and microalbuminuria (OR = 1.34, 95% CI 1.03–1.69; p = 0.019). The study showed a strong relationship between metanephrines and cardiovascular complications/metabolic alterations. Individuals with high levels of these indirect markers of sympathetic activity should be carefully monitored, and they may benefit from an aggressive treatment to reduce the cardiometabolic risk. MDPI 2021-05-04 /pmc/articles/PMC8125207/ /pubmed/34064307 http://dx.doi.org/10.3390/jcm10091967 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parasiliti-Caprino, Mirko
Obert, Chiara
Lopez, Chiara
Bollati, Martina
Bioletto, Fabio
Bima, Chiara
Egalini, Filippo
Berton, Alessandro Maria
Prencipe, Nunzia
Settanni, Fabio
Gasco, Valentina
Mengozzi, Giulio
Ghigo, Ezio
Maccario, Mauro
Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
title Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
title_full Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
title_fullStr Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
title_full_unstemmed Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
title_short Association of Urine Metanephrine Levels with CardiometaBolic Risk: An Observational Retrospective Study
title_sort association of urine metanephrine levels with cardiometabolic risk: an observational retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125207/
https://www.ncbi.nlm.nih.gov/pubmed/34064307
http://dx.doi.org/10.3390/jcm10091967
work_keys_str_mv AT parasiliticaprinomirko associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT obertchiara associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT lopezchiara associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT bollatimartina associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT biolettofabio associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT bimachiara associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT egalinifilippo associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT bertonalessandromaria associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT prencipenunzia associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT settannifabio associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT gascovalentina associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT mengozzigiulio associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT ghigoezio associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy
AT maccariomauro associationofurinemetanephrinelevelswithcardiometabolicriskanobservationalretrospectivestudy