New Crystalline Salts of Nicotinamide Riboside as Food Additives

NR(+) is a highly effective vitamin B(3) type supplement due to its unique ability to replenish NAD(+) levels. While NR(+) chloride is already on the market as a nutritional supplement, its synthesis is challenging, expensive, and low yielding, making it cumbersome for large-scale industrial production. Here we report the novel crystalline NR(+) salts, d/l/dl-hydrogen tartrate and d/l/dl-hydrogen malate. Their high-yielding, one-pot manufacture does not require specific equipment and is suitable for multi-ton scale production. These new NR(+) salts seem ideal for nutritional applications due to their bio-equivalence compared to the approved NR(+) chloride. In addition, the crystal structures of all stereoisomers of NR(+) hydrogen tartrate and NR(+) hydrogen malate and a comparison to the known NR(+) halogenides are presented.