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Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing

Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxyprop...

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Autores principales: Jin, Longhao, Park, Kyeongsoon, Yoon, Yihyun, Kim, Hyeon Soo, Kim, Hyeon Ji, Choi, Jae Won, Lee, Deuk Yong, Chun, Heung Jae, Yang, Dae Hyeok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125271/
https://www.ncbi.nlm.nih.gov/pubmed/33925687
http://dx.doi.org/10.3390/ma14092270
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author Jin, Longhao
Park, Kyeongsoon
Yoon, Yihyun
Kim, Hyeon Soo
Kim, Hyeon Ji
Choi, Jae Won
Lee, Deuk Yong
Chun, Heung Jae
Yang, Dae Hyeok
author_facet Jin, Longhao
Park, Kyeongsoon
Yoon, Yihyun
Kim, Hyeon Soo
Kim, Hyeon Ji
Choi, Jae Won
Lee, Deuk Yong
Chun, Heung Jae
Yang, Dae Hyeok
author_sort Jin, Longhao
collection PubMed
description Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. The (1)H NMR spectra of ColMA and CD-ic-TCS revealed characteristic peaks at 1.73, 5.55, 5.94, 6.43, 6.64, 6.84, 6.95, 7.31, and 7.55 ppm, indicating successful preparation of the two material types. In addition, ultraviolet–visible (UV–vis) spectroscopy proved an inclusion complex formation between HP-β-CD and TCS, judging by a unique peak observed at 280 cm(−1). Furthermore, ColMA/CD-ic-TCS exhibited an interconnected porous structure, controlled release of TCS, good biocompatibility, and antibacterial activity. By in vivo animal testing, we found that ColMA/CD-ic-TCS had a superior wound healing capacity, compared to the other hydrocolloids evaluated, due to synergistic interaction between ColMA and CD-ic-TCS. Together, our findings indicate that ColMA/CD-ic-TCS has a clinical potential as an antibacterial wound dressing.
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spelling pubmed-81252712021-05-17 Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing Jin, Longhao Park, Kyeongsoon Yoon, Yihyun Kim, Hyeon Soo Kim, Hyeon Ji Choi, Jae Won Lee, Deuk Yong Chun, Heung Jae Yang, Dae Hyeok Materials (Basel) Article Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. The (1)H NMR spectra of ColMA and CD-ic-TCS revealed characteristic peaks at 1.73, 5.55, 5.94, 6.43, 6.64, 6.84, 6.95, 7.31, and 7.55 ppm, indicating successful preparation of the two material types. In addition, ultraviolet–visible (UV–vis) spectroscopy proved an inclusion complex formation between HP-β-CD and TCS, judging by a unique peak observed at 280 cm(−1). Furthermore, ColMA/CD-ic-TCS exhibited an interconnected porous structure, controlled release of TCS, good biocompatibility, and antibacterial activity. By in vivo animal testing, we found that ColMA/CD-ic-TCS had a superior wound healing capacity, compared to the other hydrocolloids evaluated, due to synergistic interaction between ColMA and CD-ic-TCS. Together, our findings indicate that ColMA/CD-ic-TCS has a clinical potential as an antibacterial wound dressing. MDPI 2021-04-27 /pmc/articles/PMC8125271/ /pubmed/33925687 http://dx.doi.org/10.3390/ma14092270 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jin, Longhao
Park, Kyeongsoon
Yoon, Yihyun
Kim, Hyeon Soo
Kim, Hyeon Ji
Choi, Jae Won
Lee, Deuk Yong
Chun, Heung Jae
Yang, Dae Hyeok
Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
title Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
title_full Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
title_fullStr Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
title_full_unstemmed Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
title_short Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
title_sort visible light-cured antibacterial collagen hydrogel containing water-solubilized triclosan for improved wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125271/
https://www.ncbi.nlm.nih.gov/pubmed/33925687
http://dx.doi.org/10.3390/ma14092270
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