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Use of the 2D (1)H-(13)C HSQC NMR Methyl Region to Evaluate the Higher Order Structural Integrity of Biopharmaceuticals

The higher-order structure (HOS) of protein therapeutics is directly related to the function and represents a critical quality attribute. Currently, the HOS of protein therapeutics is characterized by methods with low to medium structural resolution, such as Fourier transform infrared (FTIR), circul...

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Detalles Bibliográficos
Autores principales:	Hwang, Tsang-Lin, Batabyal, Dipanwita, Knutson, Nicholas, Wikström, Mats
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125315/ https://www.ncbi.nlm.nih.gov/pubmed/34063095 http://dx.doi.org/10.3390/molecules26092714

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