Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles

Diblock copolymers based-on elastin-like polypeptide (ELP) have the potential to undergo specific phase transitions when thermally stimulated. This ability is especially suitable to form carriers, micellar structures for instance, for delivering active cargo molecules. Here, we report the design and...

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Detalles Bibliográficos
Autores principales: Dai, Michèle, Georgilis, Evangelos, Goudounet, Guillaume, Garbay, Bertrand, Pille, Jan, van Hest, Jan C. M., Schultze, Xavier, Garanger, Elisabeth, Lecommandoux, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125372/
https://www.ncbi.nlm.nih.gov/pubmed/34062852
http://dx.doi.org/10.3390/polym13091470
Descripción
Sumario:Diblock copolymers based-on elastin-like polypeptide (ELP) have the potential to undergo specific phase transitions when thermally stimulated. This ability is especially suitable to form carriers, micellar structures for instance, for delivering active cargo molecules. Here, we report the design and study of an ELP diblock library based on ELP-[M(1)V(3)-i]-[I-j]. First, ELP-[M(1)V(3)-i]-[I-j] (i = 20, 40, 60; j = 20, 90) that showed a similar self-assembly propensity (unimer-to-aggregate transition) as their related monoblocks ELP-[M(1)V(3)-i] and ELP-[I-j]. By selectively oxidizing methionines of ELP-[M(1)V(3)-i] within the different diblocks structures, we have been able to access a thermal phase transition with three distinct regimes (unimers, micelles, aggregates) characteristic of well-defined ELP diblocks.

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