Cargando…
Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey
During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125410/ https://www.ncbi.nlm.nih.gov/pubmed/33946340 http://dx.doi.org/10.3390/ijms22094768 |
_version_ | 1783693493987704832 |
---|---|
author | Larrigan, Sarah Shah, Sujay Fernandes, Alex Mattar, Pierre |
author_facet | Larrigan, Sarah Shah, Sujay Fernandes, Alex Mattar, Pierre |
author_sort | Larrigan, Sarah |
collection | PubMed |
description | During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons. |
format | Online Article Text |
id | pubmed-8125410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81254102021-05-17 Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey Larrigan, Sarah Shah, Sujay Fernandes, Alex Mattar, Pierre Int J Mol Sci Review During brain development, the genome must be repeatedly reconfigured in order to facilitate neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this process. At the genetic level, the non-redundancy of these complexes suggests that neurodevelopment may require a lexicon of remodelers with different specificities and activities. Here, we focus on the nucleosome remodeling and deacetylase (NuRD) complex. We review NuRD biochemistry, genetics, and functions in neural progenitors and neurons. MDPI 2021-04-30 /pmc/articles/PMC8125410/ /pubmed/33946340 http://dx.doi.org/10.3390/ijms22094768 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Larrigan, Sarah Shah, Sujay Fernandes, Alex Mattar, Pierre Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey |
title | Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey |
title_full | Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey |
title_fullStr | Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey |
title_full_unstemmed | Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey |
title_short | Chromatin Remodeling in the Brain-a NuRDevelopmental Odyssey |
title_sort | chromatin remodeling in the brain-a nurdevelopmental odyssey |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125410/ https://www.ncbi.nlm.nih.gov/pubmed/33946340 http://dx.doi.org/10.3390/ijms22094768 |
work_keys_str_mv | AT larrigansarah chromatinremodelinginthebrainanurdevelopmentalodyssey AT shahsujay chromatinremodelinginthebrainanurdevelopmentalodyssey AT fernandesalex chromatinremodelinginthebrainanurdevelopmentalodyssey AT mattarpierre chromatinremodelinginthebrainanurdevelopmentalodyssey |