From Channels to Canonical Wnt Signaling: A Pathological Perspective

Wnt signaling is an important pathway mainly active during embryonic development and controlling cell proliferation. This regulatory pathway is aberrantly activated in several human diseases. Ion channels are known modulators of several important cellular functions ranging from the tuning of the mem...

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Autores principales: Muccioli, Silvia, Brillo, Valentina, Chieregato, Leonardo, Leanza, Luigi, Checchetto, Vanessa, Costa, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125460/
https://www.ncbi.nlm.nih.gov/pubmed/33924772
http://dx.doi.org/10.3390/ijms22094613
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author Muccioli, Silvia
Brillo, Valentina
Chieregato, Leonardo
Leanza, Luigi
Checchetto, Vanessa
Costa, Roberto
author_facet Muccioli, Silvia
Brillo, Valentina
Chieregato, Leonardo
Leanza, Luigi
Checchetto, Vanessa
Costa, Roberto
author_sort Muccioli, Silvia
collection PubMed
description Wnt signaling is an important pathway mainly active during embryonic development and controlling cell proliferation. This regulatory pathway is aberrantly activated in several human diseases. Ion channels are known modulators of several important cellular functions ranging from the tuning of the membrane potential to modulation of intracellular pathways, in particular the influence of ion channels in Wnt signaling regulation has been widely investigated. This review will discuss the known links between ion channels and canonical Wnt signaling, focusing on their possible roles in human metabolic diseases, neurological disorders, and cancer.
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spelling pubmed-81254602021-05-17 From Channels to Canonical Wnt Signaling: A Pathological Perspective Muccioli, Silvia Brillo, Valentina Chieregato, Leonardo Leanza, Luigi Checchetto, Vanessa Costa, Roberto Int J Mol Sci Review Wnt signaling is an important pathway mainly active during embryonic development and controlling cell proliferation. This regulatory pathway is aberrantly activated in several human diseases. Ion channels are known modulators of several important cellular functions ranging from the tuning of the membrane potential to modulation of intracellular pathways, in particular the influence of ion channels in Wnt signaling regulation has been widely investigated. This review will discuss the known links between ion channels and canonical Wnt signaling, focusing on their possible roles in human metabolic diseases, neurological disorders, and cancer. MDPI 2021-04-28 /pmc/articles/PMC8125460/ /pubmed/33924772 http://dx.doi.org/10.3390/ijms22094613 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Muccioli, Silvia
Brillo, Valentina
Chieregato, Leonardo
Leanza, Luigi
Checchetto, Vanessa
Costa, Roberto
From Channels to Canonical Wnt Signaling: A Pathological Perspective
title From Channels to Canonical Wnt Signaling: A Pathological Perspective
title_full From Channels to Canonical Wnt Signaling: A Pathological Perspective
title_fullStr From Channels to Canonical Wnt Signaling: A Pathological Perspective
title_full_unstemmed From Channels to Canonical Wnt Signaling: A Pathological Perspective
title_short From Channels to Canonical Wnt Signaling: A Pathological Perspective
title_sort from channels to canonical wnt signaling: a pathological perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125460/
https://www.ncbi.nlm.nih.gov/pubmed/33924772
http://dx.doi.org/10.3390/ijms22094613
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