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The Multifaceted Roles of USP15 in Signal Transduction

Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore...

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Autores principales: Das, Tanuza, Song, Eun Joo, Kim, Eunice EunKyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125482/
https://www.ncbi.nlm.nih.gov/pubmed/33946990
http://dx.doi.org/10.3390/ijms22094728
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author Das, Tanuza
Song, Eun Joo
Kim, Eunice EunKyeong
author_facet Das, Tanuza
Song, Eun Joo
Kim, Eunice EunKyeong
author_sort Das, Tanuza
collection PubMed
description Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator.
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spelling pubmed-81254822021-05-17 The Multifaceted Roles of USP15 in Signal Transduction Das, Tanuza Song, Eun Joo Kim, Eunice EunKyeong Int J Mol Sci Review Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator. MDPI 2021-04-29 /pmc/articles/PMC8125482/ /pubmed/33946990 http://dx.doi.org/10.3390/ijms22094728 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Das, Tanuza
Song, Eun Joo
Kim, Eunice EunKyeong
The Multifaceted Roles of USP15 in Signal Transduction
title The Multifaceted Roles of USP15 in Signal Transduction
title_full The Multifaceted Roles of USP15 in Signal Transduction
title_fullStr The Multifaceted Roles of USP15 in Signal Transduction
title_full_unstemmed The Multifaceted Roles of USP15 in Signal Transduction
title_short The Multifaceted Roles of USP15 in Signal Transduction
title_sort multifaceted roles of usp15 in signal transduction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125482/
https://www.ncbi.nlm.nih.gov/pubmed/33946990
http://dx.doi.org/10.3390/ijms22094728
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