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The Multifaceted Roles of USP15 in Signal Transduction
Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125482/ https://www.ncbi.nlm.nih.gov/pubmed/33946990 http://dx.doi.org/10.3390/ijms22094728 |
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author | Das, Tanuza Song, Eun Joo Kim, Eunice EunKyeong |
author_facet | Das, Tanuza Song, Eun Joo Kim, Eunice EunKyeong |
author_sort | Das, Tanuza |
collection | PubMed |
description | Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator. |
format | Online Article Text |
id | pubmed-8125482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81254822021-05-17 The Multifaceted Roles of USP15 in Signal Transduction Das, Tanuza Song, Eun Joo Kim, Eunice EunKyeong Int J Mol Sci Review Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator. MDPI 2021-04-29 /pmc/articles/PMC8125482/ /pubmed/33946990 http://dx.doi.org/10.3390/ijms22094728 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Das, Tanuza Song, Eun Joo Kim, Eunice EunKyeong The Multifaceted Roles of USP15 in Signal Transduction |
title | The Multifaceted Roles of USP15 in Signal Transduction |
title_full | The Multifaceted Roles of USP15 in Signal Transduction |
title_fullStr | The Multifaceted Roles of USP15 in Signal Transduction |
title_full_unstemmed | The Multifaceted Roles of USP15 in Signal Transduction |
title_short | The Multifaceted Roles of USP15 in Signal Transduction |
title_sort | multifaceted roles of usp15 in signal transduction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125482/ https://www.ncbi.nlm.nih.gov/pubmed/33946990 http://dx.doi.org/10.3390/ijms22094728 |
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