Cargando…

Low Plasma Citrate Levels and Specific Transcriptional Signatures Associated with Quiescence of CD34(+) Progenitors Predict Azacitidine Therapy Failure in MDS/AML Patients

SIMPLE SUMMARY: Epigenetic drugs, such as azacitidine (AZA), hold promise in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), however, the mechanisms predicting the patients’ response to AZA is not completely understood. Quiescence of hematopoietic CD34(+) progenito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koralkova, Pavla, Belickova, Monika, Kundrat, David, Dostalova Merkerova, Michaela, Krejcik, Zdenek, Szikszai, Katarina, Kaisrlikova, Monika, Vesela, Jitka, Vyhlidalova, Pavla, Stetka, Jan, Hlavackova, Alzbeta, Suttnar, Jiri, Flodr, Patrik, Stritesky, Jan, Jonasova, Anna, Cermak, Jaroslav, Divoky, Vladimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125503/ https://www.ncbi.nlm.nih.gov/pubmed/33946220 http://dx.doi.org/10.3390/cancers13092161

Ejemplares similares

Relationship between Altered miRNA Expression and DNA Methylation of the DLK1-DIO3 Region in Azacitidine-Treated Patients with Myelodysplastic Syndromes and Acute Myeloid Leukemia with Myelodysplasia-Related Changes
por: Merkerova, Michaela Dostalova, et al.
Publicado: (2018)

LncRNA Profiling Reveals That the Deregulation of H19, WT1-AS, TCL6, and LEF1-AS1 Is Associated with Higher-Risk Myelodysplastic Syndrome
por: Szikszai, Katarina, et al.
Publicado: (2020)

Circulating Small Noncoding RNAs Have Specific Expression Patterns in Plasma and Extracellular Vesicles in Myelodysplastic Syndromes and Are Predictive of Patient Outcome
por: Hrustincova, Andrea, et al.
Publicado: (2020)

RUNX1 mutations contribute to the progression of MDS due to disruption of antitumor cellular defense: a study on patients with lower-risk MDS
por: Kaisrlikova, Monika, et al.
Publicado: (2022)

Circular RNAs in Hematopoiesis with a Focus on Acute Myeloid Leukemia and Myelodysplastic Syndrome
por: Dostalova Merkerova, Michaela, et al.
Publicado: (2020)

DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population
por: Belickova, Monika, et al.
Publicado: (2013)

Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation
por: Stetka, J., et al.
Publicado: (2019)

Modulation of the Immune Response by Deferasirox in Myelodysplastic Syndrome Patients
por: Votavova, Hana, et al.
Publicado: (2021)

Differential Expression of MicroRNAs in CD34+ Cells of 5q- Syndrome
por: Votavova, Hana, et al.
Publicado: (2011)

Role of DNA Damage Response in Suppressing Malignant Progression of Chronic Myeloid Leukemia and Polycythemia Vera: Impact of Different Oncogenes
por: Stetka, Jan, et al.
Publicado: (2020)

TP53 mutation variant allele frequency is a potential predictor for clinical outcome of patients with lower-risk myelodysplastic syndromes
por: Belickova, Monika, et al.
Publicado: (2016)

Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia
por: Kapralova, Katarina, et al.
Publicado: (2020)

Deep Molecular Response Achieved with Chemotherapy, Dasatinib and Interferon α in Patients with Lymphoid Blast Crisis of Chronic Myeloid Leukaemia
por: Vráblová, Lucia, et al.
Publicado: (2023)

Linking aberrant glycosylation of plasma glycoproteins with progression of myelodysplastic syndromes: a study based on plasmonic biosensor and lectin array
por: Chrastinová, Leona, et al.
Publicado: (2023)

Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease
por: Hajsl, Martin, et al.
Publicado: (2020)

Fibrin Clot Formation under Oxidative Stress Conditions
por: Kaufmanova, Jirina, et al.
Publicado: (2021)

A New Approach for the Diagnosis of Myelodysplastic Syndrome Subtypes Based on Protein Interaction Analysis
por: Chrastinová, Leona, et al.
Publicado: (2019)

G-CSF plus azacitidine versus azacitidine alone for patients with high-risk myelodysplastic syndrome: academic, open label, randomized trial
por: Stopka, Tomáš, et al.
Publicado: (2022)

Molecular Fingerprints of Borderline Changes in Kidney Allografts Are Influenced by Donor Category
por: Hruba, Petra, et al.
Publicado: (2020)

Long-Term Effects on the Lipidome of Acute Coronary Syndrome Patients
por: Kosek, Vít, et al.
Publicado: (2022)

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2020)

Val50Ala variant of familial amyloid neuropathy – a rare case in the Czech Republic
por: Pika, Tomas, et al.
Publicado: (2015)

Mass Spectrometry Amyloid Typing Is Reproducible across Multiple Organ Sites
por: Holub, Dusan, et al.
Publicado: (2019)

Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients
por: Malý, Martin, et al.
Publicado: (2021)

Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study
por: Svoboda, Norbert, et al.
Publicado: (2023)

circGPA: circRNA functional annotation based on probability-generating functions
por: Ryšavý, Petr, et al.
Publicado: (2022)

PB1925: VENETOCLAX IN COMBINATION WITH AZACITIDINE OR LOW-DOSE CYTARABINE IN PATIENTS WITH HIGH-RISK MDS AND AML - EXPERIENCE OF A CZECH HAEMATOLOGY CENTRE.
por: Minarik, L., et al.
Publicado: (2022)

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction
por: Dostalova, Pavla, et al.
Publicado: (2017)

Somatic mutation dynamics in MDS patients treated with azacitidine indicate clonal selection in patients-responders
por: Polgarova, Kamila, et al.
Publicado: (2017)

Plasma proteome changes associated with refractory cytopenia with multilineage dysplasia
por: Májek, Pavel, et al.
Publicado: (2011)

Plasma protein alterations in the refractory anemia with excess blasts subtype 1 subgroup of myelodysplastic syndrome
por: Májek, Pavel, et al.
Publicado: (2012)

Hypoplastic myelodysplastic syndrome and acquired aplastic anemia: Immune-mediated bone marrow failure syndromes (Review)
por: Votavova, Hana, et al.
Publicado: (2021)

First description of phosphofructokinase deficiency in spain: identification of a novel homozygous missense mutation in the PFKM gene
por: Vives-Corrons, Joan-Lluis, et al.
Publicado: (2013)

Plasma proteome changes associated with refractory anemia and refractory anemia with ringed sideroblasts in patients with myelodysplastic syndrome
por: Májek, Pavel, et al.
Publicado: (2013)

Proteome Changes in the Plasma of Myelodysplastic Syndrome Patients with Refractory Anemia with Excess Blasts Subtype 2
por: Majek, Pavel, et al.
Publicado: (2014)

Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome
por: Štikarová, Jana, et al.
Publicado: (2013)

Effect of estrogens on boar sperm capacitation in vitro
por: Ded, Lukas, et al.
Publicado: (2010)

Primitive neuroectodermal tumor (PNET) of the lung in an adult woman
por: Gachechiladze, Mariam, et al.
Publicado: (2014)

PB1776: ABC TRANSPORTERS AFFECT THE SENSITIVITY OF ACUTE MYELOID LEUKEMIA BLASTS TO CHEMOTHERAPY
por: Cerovska, E., et al.
Publicado: (2022)

The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration
por: Bechynska, Kamila, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rglh8rrol5g0ves3qcvea3t81n