Molecular Mechanism of Thymidylate Synthase Inhibition by N(4)-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies

Novel evidence is presented allowing further clarification of the mechanism of the slow-binding thymidylate synthase (TS) inhibition by N(4)-hydroxy-dCMP (N(4)-OH-dCMP). Spectrophotometric monitoring documented time- and temperature-, and N(4)-OH-dCMP-dependent TS-catalyzed dihydrofolate production,...

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Detalles Bibliográficos
Autores principales: Maj, Piotr, Jarmuła, Adam, Wilk, Piotr, Prokopowicz, Małgorzata, Rypniewski, Wojciech, Zieliński, Zbigniew, Dowierciał, Anna, Bzowska, Agnieszka, Rode, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125507/
https://www.ncbi.nlm.nih.gov/pubmed/33946210
http://dx.doi.org/10.3390/ijms22094758

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