Cargando…
Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data
We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeu...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125508/ https://www.ncbi.nlm.nih.gov/pubmed/33946914 http://dx.doi.org/10.3390/ijerph18094754 |
_version_ | 1783693523930841088 |
---|---|
author | Hernández-Rodríguez, Miguel Ángel Sempere-Verdú, Ermengol Vicens-Caldentey, Caterina González-Rubio, Francisca Miguel-García, Félix Palop-Larrea, Vicente Orueta-Sánchez, Ramón Esteban-Jiménez, Óscar Sempere-Manuel, Mara Arroyo-Aniés, María Pilar Fernández-San José, Buenaventura de Juan-Roldán, José Ignacio Ioakeim-Skoufa, Ignatios |
author_facet | Hernández-Rodríguez, Miguel Ángel Sempere-Verdú, Ermengol Vicens-Caldentey, Caterina González-Rubio, Francisca Miguel-García, Félix Palop-Larrea, Vicente Orueta-Sánchez, Ramón Esteban-Jiménez, Óscar Sempere-Manuel, Mara Arroyo-Aniés, María Pilar Fernández-San José, Buenaventura de Juan-Roldán, José Ignacio Ioakeim-Skoufa, Ignatios |
author_sort | Hernández-Rodríguez, Miguel Ángel |
collection | PubMed |
description | We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15–44 years); antidepressants, PPIs, and selective β-blockers (45–64 years); selective β-blockers, biguanides, PPIs, and statins (65–79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions’ appropriateness. |
format | Online Article Text |
id | pubmed-8125508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81255082021-05-17 Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data Hernández-Rodríguez, Miguel Ángel Sempere-Verdú, Ermengol Vicens-Caldentey, Caterina González-Rubio, Francisca Miguel-García, Félix Palop-Larrea, Vicente Orueta-Sánchez, Ramón Esteban-Jiménez, Óscar Sempere-Manuel, Mara Arroyo-Aniés, María Pilar Fernández-San José, Buenaventura de Juan-Roldán, José Ignacio Ioakeim-Skoufa, Ignatios Int J Environ Res Public Health Article We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15–44 years); antidepressants, PPIs, and selective β-blockers (45–64 years); selective β-blockers, biguanides, PPIs, and statins (65–79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions’ appropriateness. MDPI 2021-04-29 /pmc/articles/PMC8125508/ /pubmed/33946914 http://dx.doi.org/10.3390/ijerph18094754 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hernández-Rodríguez, Miguel Ángel Sempere-Verdú, Ermengol Vicens-Caldentey, Caterina González-Rubio, Francisca Miguel-García, Félix Palop-Larrea, Vicente Orueta-Sánchez, Ramón Esteban-Jiménez, Óscar Sempere-Manuel, Mara Arroyo-Aniés, María Pilar Fernández-San José, Buenaventura de Juan-Roldán, José Ignacio Ioakeim-Skoufa, Ignatios Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data |
title | Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data |
title_full | Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data |
title_fullStr | Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data |
title_full_unstemmed | Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data |
title_short | Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data |
title_sort | drug prescription profiles in patients with polypharmacy in spain: a large-scale pharmacoepidemiologic study using real-world data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125508/ https://www.ncbi.nlm.nih.gov/pubmed/33946914 http://dx.doi.org/10.3390/ijerph18094754 |
work_keys_str_mv | AT hernandezrodriguezmiguelangel drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT sempereverduermengol drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT vicenscaldenteycaterina drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT gonzalezrubiofrancisca drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT miguelgarciafelix drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT paloplarreavicente drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT oruetasanchezramon drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT estebanjimenezoscar drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT semperemanuelmara drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT arroyoaniesmariapilar drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT fernandezsanjosebuenaventura drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT dejuanroldanjoseignacio drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata AT ioakeimskoufaignatios drugprescriptionprofilesinpatientswithpolypharmacyinspainalargescalepharmacoepidemiologicstudyusingrealworlddata |