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MicroRNAs in Metastasis and the Tumour Microenvironment
Metastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. Con...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125549/ https://www.ncbi.nlm.nih.gov/pubmed/34064331 http://dx.doi.org/10.3390/ijms22094859 |
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author | Solé, Carla Lawrie, Charles Henderson |
author_facet | Solé, Carla Lawrie, Charles Henderson |
author_sort | Solé, Carla |
collection | PubMed |
description | Metastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. Consequently, there is a clear need to better understand metastasis in order to develop new tools to combat this process. MicroRNAs (miRNAs) regulate gene expression and play an important role in cancer development and progression including in the metastatic process. Particularly important are the roles that miRNAs play in the interaction between tumour cells and non-tumoral cells of the tumour microenvironment (TME), a process mediated largely by circulating miRNAs contained primarily in extracellular vesicles (EVs). In this review, we outline the accumulating evidence for the importance of miRNAs in the communication between tumour cells and the cells of the TME in the context of the pre-metastatic and metastatic niche. |
format | Online Article Text |
id | pubmed-8125549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81255492021-05-17 MicroRNAs in Metastasis and the Tumour Microenvironment Solé, Carla Lawrie, Charles Henderson Int J Mol Sci Review Metastasis is the process whereby cancer cells migrate from the primary tumour site to colonise the surrounding or distant tissue or organ. Metastasis is the primary cause of cancer-related mortality and approximately half of all cancer patients present at diagnosis with some form of metastasis. Consequently, there is a clear need to better understand metastasis in order to develop new tools to combat this process. MicroRNAs (miRNAs) regulate gene expression and play an important role in cancer development and progression including in the metastatic process. Particularly important are the roles that miRNAs play in the interaction between tumour cells and non-tumoral cells of the tumour microenvironment (TME), a process mediated largely by circulating miRNAs contained primarily in extracellular vesicles (EVs). In this review, we outline the accumulating evidence for the importance of miRNAs in the communication between tumour cells and the cells of the TME in the context of the pre-metastatic and metastatic niche. MDPI 2021-05-04 /pmc/articles/PMC8125549/ /pubmed/34064331 http://dx.doi.org/10.3390/ijms22094859 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Solé, Carla Lawrie, Charles Henderson MicroRNAs in Metastasis and the Tumour Microenvironment |
title | MicroRNAs in Metastasis and the Tumour Microenvironment |
title_full | MicroRNAs in Metastasis and the Tumour Microenvironment |
title_fullStr | MicroRNAs in Metastasis and the Tumour Microenvironment |
title_full_unstemmed | MicroRNAs in Metastasis and the Tumour Microenvironment |
title_short | MicroRNAs in Metastasis and the Tumour Microenvironment |
title_sort | micrornas in metastasis and the tumour microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125549/ https://www.ncbi.nlm.nih.gov/pubmed/34064331 http://dx.doi.org/10.3390/ijms22094859 |
work_keys_str_mv | AT solecarla micrornasinmetastasisandthetumourmicroenvironment AT lawriecharleshenderson micrornasinmetastasisandthetumourmicroenvironment |