Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1–AKT–p53 Interactions

SIMPLE SUMMARY: Cancers arising from the lining of the uterus, endometrial cancers, are the most common gynecologic malignancy in the United States. Once endometrial cancer escapes the uterus and grows in distant locations, there are limited therapeutic options. The most aggressive and lethal endome...

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Autores principales: Lynch, Katherine N., Liu, Joyce F., Kesten, Nikolas, Chow, Kin-Hoe, Shetty, Aniket, He, Ruiyang, Afreen, Mosammat Faria, Yuan, Liping, Matulonis, Ursula A., Growdon, Whitfield B., Muto, Michael G., Horowitz, Neil S., Feltmate, Colleen M., Worley, Michael J., Berkowitz, Ross S., Crum, Christopher P., Rueda, Bo R., Hill, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125555/
https://www.ncbi.nlm.nih.gov/pubmed/34063609
http://dx.doi.org/10.3390/cancers13092195

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