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Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer

Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous...

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Autores principales: Newtson, Andreea, Reyes, Henry, Devor, Eric J., Goodheart, Michael J., Bosquet, Jesus Gonzalez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125626/
https://www.ncbi.nlm.nih.gov/pubmed/33946483
http://dx.doi.org/10.3390/ijms22094791
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author Newtson, Andreea
Reyes, Henry
Devor, Eric J.
Goodheart, Michael J.
Bosquet, Jesus Gonzalez
author_facet Newtson, Andreea
Reyes, Henry
Devor, Eric J.
Goodheart, Michael J.
Bosquet, Jesus Gonzalez
author_sort Newtson, Andreea
collection PubMed
description Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion transcripts significantly associated with overall survival. Validation was performed with different analytical platforms and different algorithms to find fusion transcripts.
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spelling pubmed-81256262021-05-17 Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer Newtson, Andreea Reyes, Henry Devor, Eric J. Goodheart, Michael J. Bosquet, Jesus Gonzalez Int J Mol Sci Article Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion transcripts significantly associated with overall survival. Validation was performed with different analytical platforms and different algorithms to find fusion transcripts. MDPI 2021-04-30 /pmc/articles/PMC8125626/ /pubmed/33946483 http://dx.doi.org/10.3390/ijms22094791 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Newtson, Andreea
Reyes, Henry
Devor, Eric J.
Goodheart, Michael J.
Bosquet, Jesus Gonzalez
Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
title Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
title_full Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
title_fullStr Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
title_full_unstemmed Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
title_short Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
title_sort identification of novel fusion transcripts in high grade serous ovarian cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125626/
https://www.ncbi.nlm.nih.gov/pubmed/33946483
http://dx.doi.org/10.3390/ijms22094791
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