Cargando…
Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer
Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125626/ https://www.ncbi.nlm.nih.gov/pubmed/33946483 http://dx.doi.org/10.3390/ijms22094791 |
_version_ | 1783693559213326336 |
---|---|
author | Newtson, Andreea Reyes, Henry Devor, Eric J. Goodheart, Michael J. Bosquet, Jesus Gonzalez |
author_facet | Newtson, Andreea Reyes, Henry Devor, Eric J. Goodheart, Michael J. Bosquet, Jesus Gonzalez |
author_sort | Newtson, Andreea |
collection | PubMed |
description | Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion transcripts significantly associated with overall survival. Validation was performed with different analytical platforms and different algorithms to find fusion transcripts. |
format | Online Article Text |
id | pubmed-8125626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81256262021-05-17 Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer Newtson, Andreea Reyes, Henry Devor, Eric J. Goodheart, Michael J. Bosquet, Jesus Gonzalez Int J Mol Sci Article Fusion genes are structural chromosomal rearrangements resulting in the exchange of DNA sequences between genes. This results in the formation of a new combined gene. They have been implicated in carcinogenesis in a number of different cancers, though they have been understudied in high grade serous ovarian cancer. This study used high throughput tools to compare the transcriptome of high grade serous ovarian cancer and normal fallopian tubes in the interest of identifying unique fusion transcripts within each group. Indeed, we found that there were significantly more fusion transcripts in the cancer samples relative to the normal fallopian tubes. Following this, the role of fusion transcripts in chemo-response and overall survival was investigated. This led to the identification of fusion transcripts significantly associated with overall survival. Validation was performed with different analytical platforms and different algorithms to find fusion transcripts. MDPI 2021-04-30 /pmc/articles/PMC8125626/ /pubmed/33946483 http://dx.doi.org/10.3390/ijms22094791 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Newtson, Andreea Reyes, Henry Devor, Eric J. Goodheart, Michael J. Bosquet, Jesus Gonzalez Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer |
title | Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer |
title_full | Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer |
title_fullStr | Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer |
title_full_unstemmed | Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer |
title_short | Identification of Novel Fusion Transcripts in High Grade Serous Ovarian Cancer |
title_sort | identification of novel fusion transcripts in high grade serous ovarian cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125626/ https://www.ncbi.nlm.nih.gov/pubmed/33946483 http://dx.doi.org/10.3390/ijms22094791 |
work_keys_str_mv | AT newtsonandreea identificationofnovelfusiontranscriptsinhighgradeserousovariancancer AT reyeshenry identificationofnovelfusiontranscriptsinhighgradeserousovariancancer AT devorericj identificationofnovelfusiontranscriptsinhighgradeserousovariancancer AT goodheartmichaelj identificationofnovelfusiontranscriptsinhighgradeserousovariancancer AT bosquetjesusgonzalez identificationofnovelfusiontranscriptsinhighgradeserousovariancancer |