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IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer

SIMPLE SUMMARY: In the current study, we delineate the molecular mechanisms of acquisition of resistance to two isoform-selective inhibitors of PI3K (isiPI3K), alpelisib and taselisib, in human papillomavirus positive head and neck cell lines. By comparing RNA sequencing of isiPI3K-sensitive tumor c...

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Detalles Bibliográficos
Autores principales:	Badarni, Mai, Prasad, Manu, Golden, Artemiy, Bhattacharya, Baisali, Levin, Liron, Yegodayev, Ksenia M., Dimitstein, Orr, Joshua, Ben-Zion, Cohen, Limor, Khrameeva, Ekaterina, Kong, Dexin, Porgador, Angel, Braiman, Alex, Grandis, Jennifer R., Rotblat, Barak, Elkabets, Moshe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125641/ https://www.ncbi.nlm.nih.gov/pubmed/34067117 http://dx.doi.org/10.3390/cancers13092250

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