Cargando…

p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries

Cellular senescence and lung aging are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). COPD progresses with aging, and chronic smoking is the key susceptibility factor in lung pathological changes concurrent with mitochondrial dysfunction and biological aging. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Gagandeep, Sundar, Isaac K., Rahman, Irfan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125702/ https://www.ncbi.nlm.nih.gov/pubmed/34063608 http://dx.doi.org/10.3390/ijms22094834

Ejemplares similares

Clearance of senescent cells reverts the cigarette smoke‐induced lung senescence and airspace enlargement in p16‐3MR mice
por: Kaur, Gagandeep, et al.
Publicado: (2023)

P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence
por: Yao, Hongwei, et al.
Publicado: (2013)

Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury
por: Lerner, Chad A., et al.
Publicado: (2016)

Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema
por: Rashid, Kahkashan, et al.
Publicado: (2018)

Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD
por: Arunachalam, Gnanapragasam, et al.
Publicado: (2010)

E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts
por: Sundar, Isaac K., et al.
Publicado: (2016)

Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs
por: Khan, Naushad Ahmad, et al.
Publicado: (2019)

Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study
por: Podguski, Stephanie, et al.
Publicado: (2022)

Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice
por: Paquette, Stephen T., et al.
Publicado: (2018)

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping
por: Kaur, Gagandeep, et al.
Publicado: (2020)

Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition
por: Wang, Qixin, et al.
Publicado: (2021)

Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases
por: Manevski, Marko, et al.
Publicado: (2020)

Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis
por: Sundar, Isaac K., et al.
Publicado: (2014)

Role of mTOR in the Development of Asthma in Mice With Cigarette Smoke-Induced Cellular Senescence
por: Lee, Hyun Seung, et al.
Publicado: (2021)

p16INK4a in cellular senescence
por: Simboeck, Elisabeth, et al.
Publicado: (2013)

Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis
por: Maremanda, Krishna P., et al.
Publicado: (2020)

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis
por: Maremanda, Krishna P., et al.
Publicado: (2020)

Dysregulated Metabolites Serve as Novel Biomarkers for Metabolic Diseases Caused by E-Cigarette Vaping and Cigarette Smoking
por: Wang, Qixin, et al.
Publicado: (2021)

Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
por: Cottage, Christopher T., et al.
Publicado: (2019)

Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cigarette users, cigarette, waterpipe, and dual smokers
por: Kaur, Gagandeep, et al.
Publicado: (2020)

Cigarette smoke extract induces the senescence of endothelial progenitor cells by upregulating p300
por: Liang, Guibin, et al.
Publicado: (2023)

Epithelial Ablation of Miro1/Rhot1 GTPase Augments Lung Inflammation by Cigarette Smoke
por: Sharma, Shikha, et al.
Publicado: (2021)

Lung injury after cigarette smoking is particle related
por: Sangani, Rahul G, et al.
Publicado: (2011)

Strain‐ and sex‐dependent pulmonary toxicity of waterpipe smoke in mouse
por: Khan, Naushad Ahmad, et al.
Publicado: (2018)

Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III
por: Lei, Wei, et al.
Publicado: (2017)

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
por: Gray-Schopfer, V C, et al.
Publicado: (2006)

Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
por: Marwick, John A, et al.
Publicado: (2010)

Cellular effects of smoke from "safer" cigarettes.
por: Hopkin, J. M., et al.
Publicado: (1984)

Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis
por: Ghio, Andrew J, et al.
Publicado: (2022)

Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD
por: Maremanda, Krishna Prahlad, et al.
Publicado: (2021)

DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts
por: Han, Yaopin, et al.
Publicado: (2023)

Effects of Cigarette Smoke Extracts on the Growth and Senescence of Skin Fibroblasts In Vitro
por: Yang, Gao-yun, et al.
Publicado: (2013)

Repression of CC16 by Cigarette Smoke (CS) Exposure
por: Zhu, Lingxiang, et al.
Publicado: (2015)

Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics
por: Sundar, Isaac K., et al.
Publicado: (2011)

Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung
por: Lerner, Chad A., et al.
Publicado: (2015)

Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-κB-dependent Genes
por: Sundar, Isaac K., et al.
Publicado: (2012)

NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs
por: Chung, Sangwoon, et al.
Publicado: (2011)

Molecular and Cellular Mechanisms of Cigarette Smoke-Induced Myocardial Injury: Prevention by Vitamin C
por: Das, Archita, et al.
Publicado: (2012)

Environmental tobacco smoke exposure exaggerates bleomycin- induced collagen overexpression during pulmonary fibrogenesis
por: Wang, Qixin, et al.
Publicado: (2023)

Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C
por: Banerjee, Shuvojit, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_r51469op491m68em97pavjpbhu