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Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with...

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Autores principales: Bikov, Andras, Frent, Stefan M., Meszaros, Martina, Kunos, Laszlo, Mathioudakis, Alexander G., Negru, Alina Gabriela, Gaita, Laura, Mihaicuta, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125770/
https://www.ncbi.nlm.nih.gov/pubmed/33947164
http://dx.doi.org/10.3390/jcm10091932
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author Bikov, Andras
Frent, Stefan M.
Meszaros, Martina
Kunos, Laszlo
Mathioudakis, Alexander G.
Negru, Alina Gabriela
Gaita, Laura
Mihaicuta, Stefan
author_facet Bikov, Andras
Frent, Stefan M.
Meszaros, Martina
Kunos, Laszlo
Mathioudakis, Alexander G.
Negru, Alina Gabriela
Gaita, Laura
Mihaicuta, Stefan
author_sort Bikov, Andras
collection PubMed
description Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA.
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spelling pubmed-81257702021-05-17 Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea Bikov, Andras Frent, Stefan M. Meszaros, Martina Kunos, Laszlo Mathioudakis, Alexander G. Negru, Alina Gabriela Gaita, Laura Mihaicuta, Stefan J Clin Med Article Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA. MDPI 2021-04-29 /pmc/articles/PMC8125770/ /pubmed/33947164 http://dx.doi.org/10.3390/jcm10091932 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bikov, Andras
Frent, Stefan M.
Meszaros, Martina
Kunos, Laszlo
Mathioudakis, Alexander G.
Negru, Alina Gabriela
Gaita, Laura
Mihaicuta, Stefan
Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
title Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
title_full Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
title_fullStr Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
title_full_unstemmed Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
title_short Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea
title_sort triglyceride-glucose index in non-diabetic, non-obese patients with obstructive sleep apnoea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125770/
https://www.ncbi.nlm.nih.gov/pubmed/33947164
http://dx.doi.org/10.3390/jcm10091932
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