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Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer
SIMPLE SUMMARY: Microbiota dysbiosis is correlated with numerous diseases in the human body. To date, the research on the microbiome-associated diseases been focused on an organ-specific microbiome. However, the interorgan microbial network is emerging as an important regulator in physiological func...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125773/ https://www.ncbi.nlm.nih.gov/pubmed/33924899 http://dx.doi.org/10.3390/cancers13092124 |
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author | Park, Se-Young Hwang, Byeong-Oh Lim, Mihwa Ok, Seung-Ho Lee, Sun-Kyoung Chun, Kyung-Soo Park, Kwang-Kyun Hu, Yinling Chung, Won-Yoon Song, Na-Young |
author_facet | Park, Se-Young Hwang, Byeong-Oh Lim, Mihwa Ok, Seung-Ho Lee, Sun-Kyoung Chun, Kyung-Soo Park, Kwang-Kyun Hu, Yinling Chung, Won-Yoon Song, Na-Young |
author_sort | Park, Se-Young |
collection | PubMed |
description | SIMPLE SUMMARY: Microbiota dysbiosis is correlated with numerous diseases in the human body. To date, the research on the microbiome-associated diseases been focused on an organ-specific microbiome. However, the interorgan microbial network is emerging as an important regulator in physiological functions and pathological processes. The oral cavity and gut are the two largest microbial ecosystems. Recent studies have demonstrated that the oral-to-gut and gut-to-oral microbial transmission can regulate pathogenesis, indicating the presence of the oral–gut microbiome axis. Here, we will review the role of the oral–gut microbiome axis in gastrointestinal disease and cancer, which may provide insight for precise diagnosis/prognosis and effective treatment. ABSTRACT: It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment. |
format | Online Article Text |
id | pubmed-8125773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81257732021-05-17 Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer Park, Se-Young Hwang, Byeong-Oh Lim, Mihwa Ok, Seung-Ho Lee, Sun-Kyoung Chun, Kyung-Soo Park, Kwang-Kyun Hu, Yinling Chung, Won-Yoon Song, Na-Young Cancers (Basel) Review SIMPLE SUMMARY: Microbiota dysbiosis is correlated with numerous diseases in the human body. To date, the research on the microbiome-associated diseases been focused on an organ-specific microbiome. However, the interorgan microbial network is emerging as an important regulator in physiological functions and pathological processes. The oral cavity and gut are the two largest microbial ecosystems. Recent studies have demonstrated that the oral-to-gut and gut-to-oral microbial transmission can regulate pathogenesis, indicating the presence of the oral–gut microbiome axis. Here, we will review the role of the oral–gut microbiome axis in gastrointestinal disease and cancer, which may provide insight for precise diagnosis/prognosis and effective treatment. ABSTRACT: It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment. MDPI 2021-04-28 /pmc/articles/PMC8125773/ /pubmed/33924899 http://dx.doi.org/10.3390/cancers13092124 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Park, Se-Young Hwang, Byeong-Oh Lim, Mihwa Ok, Seung-Ho Lee, Sun-Kyoung Chun, Kyung-Soo Park, Kwang-Kyun Hu, Yinling Chung, Won-Yoon Song, Na-Young Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer |
title | Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer |
title_full | Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer |
title_fullStr | Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer |
title_full_unstemmed | Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer |
title_short | Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer |
title_sort | oral–gut microbiome axis in gastrointestinal disease and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125773/ https://www.ncbi.nlm.nih.gov/pubmed/33924899 http://dx.doi.org/10.3390/cancers13092124 |
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