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Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125876/ https://www.ncbi.nlm.nih.gov/pubmed/34066808 http://dx.doi.org/10.3390/ijms22094999 |
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author | Lee, Han Na Jeong, Mi Suk Jang, Se Bok |
author_facet | Lee, Han Na Jeong, Mi Suk Jang, Se Bok |
author_sort | Lee, Han Na |
collection | PubMed |
description | Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzheimer’s disease and to play important roles in neuronal homeostasis and development and neural transmission. APP and APLP are also expressed in non-neuronal tissues and are overexpressed in cancer cells. Furthermore, research indicates they are involved in several cancers. In this review, we examine the biological characteristics of APP-related family members and their roles in cancer. |
format | Online Article Text |
id | pubmed-8125876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81258762021-05-17 Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer Lee, Han Na Jeong, Mi Suk Jang, Se Bok Int J Mol Sci Review Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzheimer’s disease and to play important roles in neuronal homeostasis and development and neural transmission. APP and APLP are also expressed in non-neuronal tissues and are overexpressed in cancer cells. Furthermore, research indicates they are involved in several cancers. In this review, we examine the biological characteristics of APP-related family members and their roles in cancer. MDPI 2021-05-08 /pmc/articles/PMC8125876/ /pubmed/34066808 http://dx.doi.org/10.3390/ijms22094999 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Han Na Jeong, Mi Suk Jang, Se Bok Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer |
title | Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer |
title_full | Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer |
title_fullStr | Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer |
title_full_unstemmed | Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer |
title_short | Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer |
title_sort | molecular characteristics of amyloid precursor protein (app) and its effects in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125876/ https://www.ncbi.nlm.nih.gov/pubmed/34066808 http://dx.doi.org/10.3390/ijms22094999 |
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