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Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer

Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzh...

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Detalles Bibliográficos
Autores principales: Lee, Han Na, Jeong, Mi Suk, Jang, Se Bok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125876/
https://www.ncbi.nlm.nih.gov/pubmed/34066808
http://dx.doi.org/10.3390/ijms22094999
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author Lee, Han Na
Jeong, Mi Suk
Jang, Se Bok
author_facet Lee, Han Na
Jeong, Mi Suk
Jang, Se Bok
author_sort Lee, Han Na
collection PubMed
description Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzheimer’s disease and to play important roles in neuronal homeostasis and development and neural transmission. APP and APLP are also expressed in non-neuronal tissues and are overexpressed in cancer cells. Furthermore, research indicates they are involved in several cancers. In this review, we examine the biological characteristics of APP-related family members and their roles in cancer.
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spelling pubmed-81258762021-05-17 Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer Lee, Han Na Jeong, Mi Suk Jang, Se Bok Int J Mol Sci Review Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzheimer’s disease and to play important roles in neuronal homeostasis and development and neural transmission. APP and APLP are also expressed in non-neuronal tissues and are overexpressed in cancer cells. Furthermore, research indicates they are involved in several cancers. In this review, we examine the biological characteristics of APP-related family members and their roles in cancer. MDPI 2021-05-08 /pmc/articles/PMC8125876/ /pubmed/34066808 http://dx.doi.org/10.3390/ijms22094999 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Han Na
Jeong, Mi Suk
Jang, Se Bok
Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
title Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
title_full Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
title_fullStr Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
title_full_unstemmed Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
title_short Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
title_sort molecular characteristics of amyloid precursor protein (app) and its effects in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125876/
https://www.ncbi.nlm.nih.gov/pubmed/34066808
http://dx.doi.org/10.3390/ijms22094999
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