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Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (bi...

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Autores principales: Sharma, Ameya, Puri, Vivek, Kumar, Pradeep, Singh, Inderbir, Huanbutta, Kampanart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125895/
https://www.ncbi.nlm.nih.gov/pubmed/34066853
http://dx.doi.org/10.3390/polym13091514
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author Sharma, Ameya
Puri, Vivek
Kumar, Pradeep
Singh, Inderbir
Huanbutta, Kampanart
author_facet Sharma, Ameya
Puri, Vivek
Kumar, Pradeep
Singh, Inderbir
Huanbutta, Kampanart
author_sort Sharma, Ameya
collection PubMed
description Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications.
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spelling pubmed-81258952021-05-17 Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers Sharma, Ameya Puri, Vivek Kumar, Pradeep Singh, Inderbir Huanbutta, Kampanart Polymers (Basel) Article Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications. MDPI 2021-05-08 /pmc/articles/PMC8125895/ /pubmed/34066853 http://dx.doi.org/10.3390/polym13091514 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sharma, Ameya
Puri, Vivek
Kumar, Pradeep
Singh, Inderbir
Huanbutta, Kampanart
Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
title Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
title_full Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
title_fullStr Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
title_full_unstemmed Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
title_short Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
title_sort development and evaluation of rifampicin loaded alginate–gelatin biocomposite microfibers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125895/
https://www.ncbi.nlm.nih.gov/pubmed/34066853
http://dx.doi.org/10.3390/polym13091514
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