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Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers
Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (bi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125895/ https://www.ncbi.nlm.nih.gov/pubmed/34066853 http://dx.doi.org/10.3390/polym13091514 |
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author | Sharma, Ameya Puri, Vivek Kumar, Pradeep Singh, Inderbir Huanbutta, Kampanart |
author_facet | Sharma, Ameya Puri, Vivek Kumar, Pradeep Singh, Inderbir Huanbutta, Kampanart |
author_sort | Sharma, Ameya |
collection | PubMed |
description | Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications. |
format | Online Article Text |
id | pubmed-8125895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81258952021-05-17 Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers Sharma, Ameya Puri, Vivek Kumar, Pradeep Singh, Inderbir Huanbutta, Kampanart Polymers (Basel) Article Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications. MDPI 2021-05-08 /pmc/articles/PMC8125895/ /pubmed/34066853 http://dx.doi.org/10.3390/polym13091514 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sharma, Ameya Puri, Vivek Kumar, Pradeep Singh, Inderbir Huanbutta, Kampanart Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers |
title | Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers |
title_full | Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers |
title_fullStr | Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers |
title_full_unstemmed | Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers |
title_short | Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers |
title_sort | development and evaluation of rifampicin loaded alginate–gelatin biocomposite microfibers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125895/ https://www.ncbi.nlm.nih.gov/pubmed/34066853 http://dx.doi.org/10.3390/polym13091514 |
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