Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis, we analyzed serial samples from 207 SARS-CoV2-infected individuals with a range of disease severities over 12 weeks from symp...

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Detalles Bibliográficos
Autores principales: Bergamaschi, Laura, Mescia, Federica, Turner, Lorinda, Hanson, Aimee L., Kotagiri, Prasanti, Dunmore, Benjamin J., Ruffieux, Hélène, De Sa, Aloka, Huhn, Oisín, Morgan, Michael D., Gerber, Pehuén Pereyra, Wills, Mark R., Baker, Stephen, Calero-Nieto, Fernando J., Doffinger, Rainer, Dougan, Gordon, Elmer, Anne, Goodfellow, Ian G., Gupta, Ravindra K., Hosmillo, Myra, Hunter, Kelvin, Kingston, Nathalie, Lehner, Paul J., Matheson, Nicholas J., Nicholson, Jeremy K., Petrunkina, Anna M., Richardson, Sylvia, Saunders, Caroline, Thaventhiran, James E.D., Toonen, Erik J.M., Weekes, Michael P., Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Bradley, John R., Lyons, Paul A., Smith, Kenneth G.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125900/
https://www.ncbi.nlm.nih.gov/pubmed/34051148
http://dx.doi.org/10.1016/j.immuni.2021.05.010

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