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Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report
OBJECTIVES: To report the postmortem findings of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individual who died in Lagos (Nigeria) in June 2020 and to investigate the cause, pathogenesis as well as pathological changes noticed during the examination. METHODS: Complete po...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125910/ https://www.ncbi.nlm.nih.gov/pubmed/34026549 http://dx.doi.org/10.1016/j.ehpc.2021.200524 |
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author | Keshinro, Samuel Olalekan Awolola, Nicholas Awodele Adebayo, Luqman Adedotun Mutiu, Wasiu Bamidele Saka, Babatunde Akeem Abdus-Salam, Ismail Adeshina |
author_facet | Keshinro, Samuel Olalekan Awolola, Nicholas Awodele Adebayo, Luqman Adedotun Mutiu, Wasiu Bamidele Saka, Babatunde Akeem Abdus-Salam, Ismail Adeshina |
author_sort | Keshinro, Samuel Olalekan |
collection | PubMed |
description | OBJECTIVES: To report the postmortem findings of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individual who died in Lagos (Nigeria) in June 2020 and to investigate the cause, pathogenesis as well as pathological changes noticed during the examination. METHODS: Complete postmortem examination was performed according to standard procedures in a regular autopsy suite using personal protective equipment including N95 masks, goggles and disposable gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) testing on postmortem nasopharyngeal swabs. RESULTS: A 47-year-old man with a medical history of well controlled hypertension and dyslipidaemia died after long hours of transportation for medical care in a hospital in Lagos. He tested positive for SARS-CoV-2 on ante- and postmortem nasopharyngeal swabs. Autopsy revealed pneumonia with diffuse alveolar damage, disseminated intravascular coagulopathy and hypovolaemic shock. CONCLUSIONS: Autopsy can be performed on decedents who died from or with SARS-CoV-2 infection in a low resource environment such as ours. A standard autopsy room was used while deploying recommended infection prevention control and regular decontamination. The clinical details, autopsy findings such as diffuse alveolar damage and airway inflammation were consistent with a COVID-19 related pathology. While the decedent had ‘controlled’ co-morbidity, he succumbed to multi-organ failure occasioned by shock and disseminated intravascular coagulopathy. |
format | Online Article Text |
id | pubmed-8125910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Author(s). Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81259102021-05-17 Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report Keshinro, Samuel Olalekan Awolola, Nicholas Awodele Adebayo, Luqman Adedotun Mutiu, Wasiu Bamidele Saka, Babatunde Akeem Abdus-Salam, Ismail Adeshina Hum Pathol (N Y) Article OBJECTIVES: To report the postmortem findings of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individual who died in Lagos (Nigeria) in June 2020 and to investigate the cause, pathogenesis as well as pathological changes noticed during the examination. METHODS: Complete postmortem examination was performed according to standard procedures in a regular autopsy suite using personal protective equipment including N95 masks, goggles and disposable gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) testing on postmortem nasopharyngeal swabs. RESULTS: A 47-year-old man with a medical history of well controlled hypertension and dyslipidaemia died after long hours of transportation for medical care in a hospital in Lagos. He tested positive for SARS-CoV-2 on ante- and postmortem nasopharyngeal swabs. Autopsy revealed pneumonia with diffuse alveolar damage, disseminated intravascular coagulopathy and hypovolaemic shock. CONCLUSIONS: Autopsy can be performed on decedents who died from or with SARS-CoV-2 infection in a low resource environment such as ours. A standard autopsy room was used while deploying recommended infection prevention control and regular decontamination. The clinical details, autopsy findings such as diffuse alveolar damage and airway inflammation were consistent with a COVID-19 related pathology. While the decedent had ‘controlled’ co-morbidity, he succumbed to multi-organ failure occasioned by shock and disseminated intravascular coagulopathy. The Author(s). Published by Elsevier Inc. 2021-06 2021-05-16 /pmc/articles/PMC8125910/ /pubmed/34026549 http://dx.doi.org/10.1016/j.ehpc.2021.200524 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Keshinro, Samuel Olalekan Awolola, Nicholas Awodele Adebayo, Luqman Adedotun Mutiu, Wasiu Bamidele Saka, Babatunde Akeem Abdus-Salam, Ismail Adeshina Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report |
title | Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report |
title_full | Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report |
title_fullStr | Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report |
title_full_unstemmed | Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report |
title_short | Full autopsy in a confirmed COVID-19 patient in Lagos, Nigeria – A case report |
title_sort | full autopsy in a confirmed covid-19 patient in lagos, nigeria – a case report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125910/ https://www.ncbi.nlm.nih.gov/pubmed/34026549 http://dx.doi.org/10.1016/j.ehpc.2021.200524 |
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