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HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients

Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19). We aimed to identify the cytokines responsible for lung damage and mortality. We prospectively recruited 108 COVID-19 patients between March and April 2020 and divided them into four groups acc...

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Autores principales: Tamayo-Velasco, Álvaro, Martínez-Paz, Pedro, Peñarrubia-Ponce, María Jesús, de la Fuente, Ignacio, Pérez-González, Sonia, Fernández, Itziar, Dueñas, Carlos, Gómez-Sánchez, Esther, Lorenzo-López, Mario, Gómez-Pesquera, Estefanía, Heredia-Rodríguez, María, Carnicero-Frutos, Irene, Muñoz-Moreno, María Fe, Bernardo, David, Álvarez, Francisco Javier, Tamayo, Eduardo, Gonzalo-Benito, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125923/
https://www.ncbi.nlm.nih.gov/pubmed/34066892
http://dx.doi.org/10.3390/jcm10092017
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author Tamayo-Velasco, Álvaro
Martínez-Paz, Pedro
Peñarrubia-Ponce, María Jesús
de la Fuente, Ignacio
Pérez-González, Sonia
Fernández, Itziar
Dueñas, Carlos
Gómez-Sánchez, Esther
Lorenzo-López, Mario
Gómez-Pesquera, Estefanía
Heredia-Rodríguez, María
Carnicero-Frutos, Irene
Muñoz-Moreno, María Fe
Bernardo, David
Álvarez, Francisco Javier
Tamayo, Eduardo
Gonzalo-Benito, Hugo
author_facet Tamayo-Velasco, Álvaro
Martínez-Paz, Pedro
Peñarrubia-Ponce, María Jesús
de la Fuente, Ignacio
Pérez-González, Sonia
Fernández, Itziar
Dueñas, Carlos
Gómez-Sánchez, Esther
Lorenzo-López, Mario
Gómez-Pesquera, Estefanía
Heredia-Rodríguez, María
Carnicero-Frutos, Irene
Muñoz-Moreno, María Fe
Bernardo, David
Álvarez, Francisco Javier
Tamayo, Eduardo
Gonzalo-Benito, Hugo
author_sort Tamayo-Velasco, Álvaro
collection PubMed
description Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19). We aimed to identify the cytokines responsible for lung damage and mortality. We prospectively recruited 108 COVID-19 patients between March and April 2020 and divided them into four groups according to the severity of respiratory symptoms. Twenty-eight healthy volunteers were used for normalization of the results. Multiple cytokines showed statistically significant differences between mild and critical patients. High HGF levels were associated with the critical group (OR = 3.51; p < 0.001; 95%CI = 1.95–6.33). Moreover, high IL-1α (OR = 1.36; p = 0.01; 95%CI = 1.07–1.73) and low IL-27 (OR = 0.58; p < 0.005; 95%CI = 0.39–0.85) greatly increased the risk of ending up in the severe group. This model was especially sensitive in order to predict critical status (AUC = 0.794; specificity = 69.74%; sensitivity = 81.25%). Furthermore, high levels of HGF and IL-1α showed significant results in the survival analysis (p = 0.033 and p = 0.011, respectively). HGF, IL-1α, and IL 27 at hospital admission were strongly associated with severe/critical COVID-19 patients and therefore are excellent predictors of bad prognosis. HGF and IL-1α were also mortality biomarkers.
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spelling pubmed-81259232021-05-17 HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients Tamayo-Velasco, Álvaro Martínez-Paz, Pedro Peñarrubia-Ponce, María Jesús de la Fuente, Ignacio Pérez-González, Sonia Fernández, Itziar Dueñas, Carlos Gómez-Sánchez, Esther Lorenzo-López, Mario Gómez-Pesquera, Estefanía Heredia-Rodríguez, María Carnicero-Frutos, Irene Muñoz-Moreno, María Fe Bernardo, David Álvarez, Francisco Javier Tamayo, Eduardo Gonzalo-Benito, Hugo J Clin Med Article Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19). We aimed to identify the cytokines responsible for lung damage and mortality. We prospectively recruited 108 COVID-19 patients between March and April 2020 and divided them into four groups according to the severity of respiratory symptoms. Twenty-eight healthy volunteers were used for normalization of the results. Multiple cytokines showed statistically significant differences between mild and critical patients. High HGF levels were associated with the critical group (OR = 3.51; p < 0.001; 95%CI = 1.95–6.33). Moreover, high IL-1α (OR = 1.36; p = 0.01; 95%CI = 1.07–1.73) and low IL-27 (OR = 0.58; p < 0.005; 95%CI = 0.39–0.85) greatly increased the risk of ending up in the severe group. This model was especially sensitive in order to predict critical status (AUC = 0.794; specificity = 69.74%; sensitivity = 81.25%). Furthermore, high levels of HGF and IL-1α showed significant results in the survival analysis (p = 0.033 and p = 0.011, respectively). HGF, IL-1α, and IL 27 at hospital admission were strongly associated with severe/critical COVID-19 patients and therefore are excellent predictors of bad prognosis. HGF and IL-1α were also mortality biomarkers. MDPI 2021-05-08 /pmc/articles/PMC8125923/ /pubmed/34066892 http://dx.doi.org/10.3390/jcm10092017 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tamayo-Velasco, Álvaro
Martínez-Paz, Pedro
Peñarrubia-Ponce, María Jesús
de la Fuente, Ignacio
Pérez-González, Sonia
Fernández, Itziar
Dueñas, Carlos
Gómez-Sánchez, Esther
Lorenzo-López, Mario
Gómez-Pesquera, Estefanía
Heredia-Rodríguez, María
Carnicero-Frutos, Irene
Muñoz-Moreno, María Fe
Bernardo, David
Álvarez, Francisco Javier
Tamayo, Eduardo
Gonzalo-Benito, Hugo
HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
title HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
title_full HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
title_fullStr HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
title_full_unstemmed HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
title_short HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
title_sort hgf, il-1α, and il-27 are robust biomarkers in early severity stratification of covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125923/
https://www.ncbi.nlm.nih.gov/pubmed/34066892
http://dx.doi.org/10.3390/jcm10092017
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