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Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?

Introduction: Fungal infections remain a major challenge affecting outcomes after kidney (KT) and liver transplantation (LT). Methods: In this retrospective single center study, the incidence of Candida contamination in renal and hepatic graft preservation solution (PS) was evaluated. In addition, C...

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Autores principales: Stern, Sabrina, Bezinover, Dmitri, Rath, Peter-M., Paul, Andreas, Saner, Fuat H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125956/
https://www.ncbi.nlm.nih.gov/pubmed/34065096
http://dx.doi.org/10.3390/jcm10092022
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author Stern, Sabrina
Bezinover, Dmitri
Rath, Peter-M.
Paul, Andreas
Saner, Fuat H.
author_facet Stern, Sabrina
Bezinover, Dmitri
Rath, Peter-M.
Paul, Andreas
Saner, Fuat H.
author_sort Stern, Sabrina
collection PubMed
description Introduction: Fungal infections remain a major challenge affecting outcomes after kidney (KT) and liver transplantation (LT). Methods: In this retrospective single center study, the incidence of Candida contamination in renal and hepatic graft preservation solution (PS) was evaluated. In addition, Candida associated infections in recipients and related complications were analyzed. Results: Overall, the PS of 1248 hepatic and 1273 renal grafts were evaluated. The incidence of fungal contamination in the PS of hepatic and renal grafts was 1.2% and 0.86%, respectively. Additionally, the hepatic PS of one patient who underwent a combined liver–kidney transplant had Candida contamination. Candida albicans was the most common organism (70.4%) and 65.4% of the patients received antifungal treatment. Candida-associated complications in the recipients was 19%. Complications in LT patients included Candida peritonitis and Candida sepsis. Two KT recipients with contaminated PS developed a mycotic aneurysm at the anastomotic site resulting in severe bleeding. The 1-year mortality in patients with PS contamination for LT and KT recipients was 33% and 18%, respectively. Although the incidence of fungal contamination of PS was low, contaminated PS was associated with a high mortality. Conclusion: The results of the study suggest that PS should be evaluated for fungal growth.
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spelling pubmed-81259562021-05-17 Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter? Stern, Sabrina Bezinover, Dmitri Rath, Peter-M. Paul, Andreas Saner, Fuat H. J Clin Med Article Introduction: Fungal infections remain a major challenge affecting outcomes after kidney (KT) and liver transplantation (LT). Methods: In this retrospective single center study, the incidence of Candida contamination in renal and hepatic graft preservation solution (PS) was evaluated. In addition, Candida associated infections in recipients and related complications were analyzed. Results: Overall, the PS of 1248 hepatic and 1273 renal grafts were evaluated. The incidence of fungal contamination in the PS of hepatic and renal grafts was 1.2% and 0.86%, respectively. Additionally, the hepatic PS of one patient who underwent a combined liver–kidney transplant had Candida contamination. Candida albicans was the most common organism (70.4%) and 65.4% of the patients received antifungal treatment. Candida-associated complications in the recipients was 19%. Complications in LT patients included Candida peritonitis and Candida sepsis. Two KT recipients with contaminated PS developed a mycotic aneurysm at the anastomotic site resulting in severe bleeding. The 1-year mortality in patients with PS contamination for LT and KT recipients was 33% and 18%, respectively. Although the incidence of fungal contamination of PS was low, contaminated PS was associated with a high mortality. Conclusion: The results of the study suggest that PS should be evaluated for fungal growth. MDPI 2021-05-09 /pmc/articles/PMC8125956/ /pubmed/34065096 http://dx.doi.org/10.3390/jcm10092022 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stern, Sabrina
Bezinover, Dmitri
Rath, Peter-M.
Paul, Andreas
Saner, Fuat H.
Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?
title Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?
title_full Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?
title_fullStr Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?
title_full_unstemmed Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?
title_short Candida Contamination in Kidney and Liver Organ Preservation Solution: Does It Matter?
title_sort candida contamination in kidney and liver organ preservation solution: does it matter?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125956/
https://www.ncbi.nlm.nih.gov/pubmed/34065096
http://dx.doi.org/10.3390/jcm10092022
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