Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients

Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon...

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Detalles Bibliográficos
Autores principales: Oliveres, Helena, Pesántez, David, Maurel, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126031/
https://www.ncbi.nlm.nih.gov/pubmed/34065119
http://dx.doi.org/10.3390/ijms22095019
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author Oliveres, Helena
Pesántez, David
Maurel, Joan
author_facet Oliveres, Helena
Pesántez, David
Maurel, Joan
author_sort Oliveres, Helena
collection PubMed
description Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon cancer. The main IGF1R signaling pathways are PI3K-AKT and MAPK-MEK. However, different processes, such as post-translational modification (SUMOylation), epithelial-to-mesenchymal transition (EMT), and microenvironment complexity, can also contribute to intrinsic and acquired resistance. Here, we discuss new strategies for adequate drug development in metastatic colorectal cancer patients.
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spelling pubmed-81260312021-05-17 Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients Oliveres, Helena Pesántez, David Maurel, Joan Int J Mol Sci Review Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon cancer. The main IGF1R signaling pathways are PI3K-AKT and MAPK-MEK. However, different processes, such as post-translational modification (SUMOylation), epithelial-to-mesenchymal transition (EMT), and microenvironment complexity, can also contribute to intrinsic and acquired resistance. Here, we discuss new strategies for adequate drug development in metastatic colorectal cancer patients. MDPI 2021-05-09 /pmc/articles/PMC8126031/ /pubmed/34065119 http://dx.doi.org/10.3390/ijms22095019 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliveres, Helena
Pesántez, David
Maurel, Joan
Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients
title Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients
title_full Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients
title_fullStr Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients
title_full_unstemmed Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients
title_short Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients
title_sort lessons to learn for adequate targeted therapy development in metastatic colorectal cancer patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126031/
https://www.ncbi.nlm.nih.gov/pubmed/34065119
http://dx.doi.org/10.3390/ijms22095019
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AT maureljoan lessonstolearnforadequatetargetedtherapydevelopmentinmetastaticcolorectalcancerpatients

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