Cargando…

The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population

BACKGROUND: The albumin-to-alkaline phosphatase ratio (AAPR) is a newly developed index of liver function, but its association in patients with non-alcoholic fatty liver disease (NAFLD) has not been established. The aim of this study was to investigate the association between the AAPR and NAFLD in a...

Descripción completa

Detalles Bibliográficos
Autores principales: Sheng, Guotai, Peng, Nan, Hu, Chong, Zhong, Ling, Zhong, Mingchun, Zou, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126124/
https://www.ncbi.nlm.nih.gov/pubmed/33993872
http://dx.doi.org/10.1186/s12944-021-01479-9
_version_ 1783693707308957696
author Sheng, Guotai
Peng, Nan
Hu, Chong
Zhong, Ling
Zhong, Mingchun
Zou, Yang
author_facet Sheng, Guotai
Peng, Nan
Hu, Chong
Zhong, Ling
Zhong, Mingchun
Zou, Yang
author_sort Sheng, Guotai
collection PubMed
description BACKGROUND: The albumin-to-alkaline phosphatase ratio (AAPR) is a newly developed index of liver function, but its association in patients with non-alcoholic fatty liver disease (NAFLD) has not been established. The aim of this study was to investigate the association between the AAPR and NAFLD in a non-obese Chinese population. METHODS: The study included 10,749 non-obese subjects without NAFLD at baseline and divided them into quintiles according to the AAPR. A Cox multiple regression model was used to examine the association between the AAPR and its quintiles and the incidence of NAFLD. RESULTS: The average age of the study population was 43.65 ± 15.15 years old. During the 5-year follow-up, 1860 non-obese subjects had NAFLD events. In the Cox multiple regression model, after adjusting the model according to important risk factors, the AAPR and NAFLD risk were independently correlated, and with a gradual increase in the AAPR, the NAFLD risk decreased gradually (HR: 0.61, 95% CI: 0.47, 0.81; P-trend< 0.0001). Additionally, there were significant interactions between the AAPR and BMI, blood pressure and lipids (P-interaction < 0.05). Stratified analysis showed that the risk of AAPR-related NAFLD decreased in people with normal blood pressure and lipid levels, while the risk of AAPR-related NAFLD increased abnormally in people who were underweight. CONCLUSIONS: This longitudinal cohort study provides the first evidence that the AAPR is an independent predictor of future NAFLD events in non-obese people. For non-obese people with a low AAPR, especially those with BMI < 18.5 kg/m(2), more attention should be given to the management of risk factors for NAFLD to prevent future NAFLD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-021-01479-9.
format Online
Article
Text
id pubmed-8126124
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-81261242021-05-17 The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population Sheng, Guotai Peng, Nan Hu, Chong Zhong, Ling Zhong, Mingchun Zou, Yang Lipids Health Dis Research BACKGROUND: The albumin-to-alkaline phosphatase ratio (AAPR) is a newly developed index of liver function, but its association in patients with non-alcoholic fatty liver disease (NAFLD) has not been established. The aim of this study was to investigate the association between the AAPR and NAFLD in a non-obese Chinese population. METHODS: The study included 10,749 non-obese subjects without NAFLD at baseline and divided them into quintiles according to the AAPR. A Cox multiple regression model was used to examine the association between the AAPR and its quintiles and the incidence of NAFLD. RESULTS: The average age of the study population was 43.65 ± 15.15 years old. During the 5-year follow-up, 1860 non-obese subjects had NAFLD events. In the Cox multiple regression model, after adjusting the model according to important risk factors, the AAPR and NAFLD risk were independently correlated, and with a gradual increase in the AAPR, the NAFLD risk decreased gradually (HR: 0.61, 95% CI: 0.47, 0.81; P-trend< 0.0001). Additionally, there were significant interactions between the AAPR and BMI, blood pressure and lipids (P-interaction < 0.05). Stratified analysis showed that the risk of AAPR-related NAFLD decreased in people with normal blood pressure and lipid levels, while the risk of AAPR-related NAFLD increased abnormally in people who were underweight. CONCLUSIONS: This longitudinal cohort study provides the first evidence that the AAPR is an independent predictor of future NAFLD events in non-obese people. For non-obese people with a low AAPR, especially those with BMI < 18.5 kg/m(2), more attention should be given to the management of risk factors for NAFLD to prevent future NAFLD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-021-01479-9. BioMed Central 2021-05-16 /pmc/articles/PMC8126124/ /pubmed/33993872 http://dx.doi.org/10.1186/s12944-021-01479-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Sheng, Guotai
Peng, Nan
Hu, Chong
Zhong, Ling
Zhong, Mingchun
Zou, Yang
The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population
title The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population
title_full The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population
title_fullStr The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population
title_full_unstemmed The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population
title_short The albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese Chinese population
title_sort albumin-to-alkaline phosphatase ratio as an independent predictor of future non-alcoholic fatty liver disease in a 5-year longitudinal cohort study of a non-obese chinese population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126124/
https://www.ncbi.nlm.nih.gov/pubmed/33993872
http://dx.doi.org/10.1186/s12944-021-01479-9
work_keys_str_mv AT shengguotai thealbumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT pengnan thealbumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT huchong thealbumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT zhongling thealbumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT zhongmingchun thealbumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT zouyang thealbumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT shengguotai albumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT pengnan albumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT huchong albumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT zhongling albumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT zhongmingchun albumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation
AT zouyang albumintoalkalinephosphataseratioasanindependentpredictoroffuturenonalcoholicfattyliverdiseaseina5yearlongitudinalcohortstudyofanonobesechinesepopulation