Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

BACKGROUND: A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes, inhibiting B should kill cancer cells with a defect on A, and shoul...

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Detalles Bibliográficos
Autores principales: Pinoli, Pietro, Srihari, Sriganesh, Wong, Limsoon, Ceri, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126165/
https://www.ncbi.nlm.nih.gov/pubmed/33992077
http://dx.doi.org/10.1186/s12859-021-04168-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126165/
https://www.ncbi.nlm.nih.gov/pubmed/33992077
http://dx.doi.org/10.1186/s12859-021-04168-7

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